Western Blot (WB)
(Western Blot (WB) analysis of LYL1 polyclonal antibody at 1:500 Line1:HEK293T whole cell lysateLine2:H9C2 whole cell lysateLine3:Raw264. 7 whole cell lysate)
Rabbit LYL1 Polyclonal Antibody | anti-LYL1 antibody
LYL1 Polyclonal Antibody
Gene Names
LYL1; bHLHa18
Reactivity
Human, Mouse, Rat
Applications
Western Blot
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Synonyms
LYL1; Polyclonal Antibody; LYL1 Polyclonal Antibody; Protein lyl-1; Class A basic helix-loop-helix protein 18; bHLHa18; Lymphoblastic leukemia-derived sequence 1; BHLHA18; anti-LYL1 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
LYL1 polyclonal antibody detects endogenous levels LYL1 protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Form/Format
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Sequence Length
280
Applicable Applications for anti-LYL1 antibody
Western Blot (WB)
Application Notes
WB: 1:500-1:1000
Immunogen
A synthetic peptide corresponding to residues in Human LYL1.
Preparation and Storage
Store at 4 degree C short term.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Western Blot (WB)
(Western Blot (WB) analysis of LYL1 polyclonal antibody at 1:500 Line1:HEK293T whole cell lysateLine2:H9C2 whole cell lysateLine3:Raw264. 7 whole cell lysate)
Western Blot (WB)
(Western Blot (WB) analysis of LYL1 polyclonal antibody at 1:500 Line1:HEK293T whole cell lysateLine2:H9C2 whole cell lysateLine3:Raw264. 7 whole cell lysate)
Related Product Information for anti-LYL1 antibody
Lyl-1, TAL1 and TAL2 are part of a family of basic helix-loop-helix (bHLH) proteins implicated in T cell acute leukemia. TAL1, also designated SCL, is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. TAL2 is a protein involved in T cell acute lymphoblastic leukemia through a chromosomal translocation involving TAL2 and T cell receptor beta chain genes. TAL2 includes a helix-loop-helix protein dimerization and DNA-binding domain that is homologous to TAL1 and Lyl-1 proto-oncogenes. Lyl-1 (lymphoblastic leukemia-derived sequence 1) is a nuclear protein. Endogenous Lyl-1 exists in complex with E2alpha proteins. Lyl-1 and E2alpha protein can form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells. Lyl-1 is involved in a chromosomal aberration which causes a form of T cell acute lymphoblastic leukemia (T-ALL).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
~ 30kDa
NCBI Official Full Name
protein lyl-1
NCBI Official Synonym Full Names
LYL1 basic helix-loop-helix family member
NCBI Official Symbol
LYL1
NCBI Official Synonym Symbols
bHLHa18
NCBI Protein Information
protein lyl-1
UniProt Protein Name
Protein lyl-1
Protein Family
UniProt Gene Name
LYL1
UniProt Synonym Gene Names
BHLHA18; bHLHa18
UniProt Entry Name
LYL1_HUMAN
NCBI Description
This gene represents a basic helix-loop-helix transcription factor. The encoded protein may play roles in blood vessel maturation and hematopoeisis. A translocation between this locus and the T cell receptor beta locus (GeneID 6957) on chromosome 7 has been associated with acute lymphoblastic leukemia. [provided by RefSeq, Sep 2010]
Uniprot Description
LYL1: A chromosomal aberration involving LYL1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(7;19)(q35;p13) with TCRB.
Protein type: DNA-binding; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: nucleus
Molecular Function: protein dimerization activity; protein binding; DNA binding
Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; B cell differentiation; blood vessel maturation
Research Articles on LYL1
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Product Notes
The LYL1 lyl1 (Catalog #AAA3007179) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The LYL1 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's LYL1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500-1:1000. Researchers should empirically determine the suitability of the LYL1 lyl1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LYL1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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