Rabbit anti-Human LRRC33 Polyclonal Antibody | anti-NRROS antibody

LRRC33, CT (LRRC33, Leucine-rich repeat-containing protein 33)

Cat. Num. AAA641837

• Gene Names: NRROS; GARPL1; LRRC33; UNQ3030
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: LRRC33; Polyclonal Antibody; CT (LRRC33; Leucine-rich repeat-containing protein 33); Anti -LRRC33; anti-NRROS antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-NRROS antibody: ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Western Blot, Immunohistochemistry, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500; Immunohistochemistry: 1:50-100
• Immunogen: LRRC33 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 618-648 amino acids from the C-terminal region of human LRRC33.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis in HepG2 cell line lysates (35ug/lane) using MBS641837. This demonstrates MBS641837 detected the LRRC33 protein (arrow).)

Immunohistochemistry (IHC)

(Immunohistochemistry analysis in formalin fixed and paraffin embedded human lymph node using MBS641837 followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of MBS641837 for immunohistochemistry.)

Product Categories/Family for anti-NRROS antibody

Antibodies; Abs to Leucine-rich Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 38348406
• NCBI GeneID: 375387
• NCBI Accession #: NP_940967.1
• NCBI GenBank Nucleotide #: NM_198565.1
• UniProt Accession #: Q86YC3
• Molecular Weight: 76,366 Da
• NCBI Official Full Name: leucine-rich repeat-containing protein 33
• NCBI Official Synonym Full Names: negative regulator of reactive oxygen species
• NCBI Official Symbol: NRROS
• NCBI Official Synonym Symbols: GARPL1; LRRC33; UNQ3030
• NCBI Protein Information: leucine-rich repeat-containing protein 33; ELLP3030; leucine rich repeat containing 33
• UniProt Protein Name: Leucine-rich repeat-containing protein 33
• Protein Family: Negative regulator of reactive oxygen species
• UniProt Gene Name: NRROS
• UniProt Synonym Gene Names: LRRC33
• UniProt Entry Name: LRC33_HUMAN

Uniprot Description

NRROS: May play a critical role in desensitizing TLR signaling through inhibition of Toll-like receptor-mediated NF-kappa-B activation and cytokine production. Interacts (via LRR repeats) with TLR2, TLR3, TLR4, TLR9 and probably other Toll-like receptors

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q29

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane; plasma membrane

Biological Process: superoxide metabolic process; innate immune response; immune response; inflammatory response