Rabbit anti-Human AEBP1 Polyclonal Antibody | anti-AEBP1 antibody

AEBP1 Antibody

Cat. Num. AAA9411004

• Gene Names: AEBP1; ACLP
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: AEBP1; Polyclonal Antibody; AEBP1 Antibody; ACLP; anti-AEBP1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total AEBP1 protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
• Concentration: 1.5 mg/ml (varies by lot)
• Sequence Length: 1158

• Applicable Applications for anti-AEBP1 antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:25-1:100
• Immunogen Type: Peptide
• Immunogen Description: Synthetic peptide of human AE binding protein 1
• Target Name: AEBP1
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue using at dilution 1/25.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/25.)

Related Product Information for anti-AEBP1 antibody

This gene encodes a member of carboxypeptidase A protein family. The encoded protein may function as a transcriptional repressor and play a role in adipogenesis and smooth muscle cell differentiation. Studies in mice suggest that this gene functions in wound healing and abdominal wall development. Overexpression of this gene is associated with glioblastoma.

Product Categories/Family for anti-AEBP1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 53692189
• NCBI GeneID: 165
• NCBI Accession #: NP_001120.3
• NCBI GenBank Nucleotide #: NM_001129.4
• UniProt Accession #: Q8IUX7; Q14113; Q59ER7; Q6ZSC7; Q7KZ79
• Molecular Weight: 82,183 Da
• NCBI Official Full Name: adipocyte enhancer-binding protein 1
• NCBI Official Synonym Full Names: AE binding protein 1
• NCBI Official Symbol: AEBP1
• NCBI Official Synonym Symbols: ACLP
• NCBI Protein Information: adipocyte enhancer-binding protein 1
• UniProt Protein Name: Adipocyte enhancer-binding protein 1
• Protein Family: Adipocyte enhancer-binding protein
• UniProt Gene Name: AEBP1
• UniProt Synonym Gene Names: ACLP; AE-binding protein 1
• UniProt Entry Name: AEBP1_HUMAN

NCBI Description

This gene encodes a member of carboxypeptidase A protein family. The encoded protein may function as a transcriptional repressor and play a role in adipogenesis and smooth muscle cell differentiation. Studies in mice suggest that this gene functions in wound healing and abdominal wall development. Overexpression of this gene is associated with glioblastoma. [provided by RefSeq, May 2013]

Uniprot Description

AEBP1: May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I- kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor. Belongs to the peptidase M14 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide; Transcription factor

Chromosomal Location of Human Ortholog: 7p13

Cellular Component: extracellular matrix; extracellular space; cytoplasm; nucleus

Molecular Function: calmodulin binding; zinc ion binding; carboxypeptidase activity; transcription factor activity; metallocarboxypeptidase activity; transcription corepressor activity

Biological Process: muscle development; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; proteolysis; skeletal development