Rabbit LRP1 Polyclonal Antibody | anti-LRP1 antibody

Anti-LRP1 Antibody, Rabbit Polyclonal

Cat. Num. AAA8101915

• Gene Names: Lrp1; Lrp; A2mr; CD91; AI316852; b2b1554Clo
• Reactivity: Mouse; Predicted to React with: Human (Species predicted to react based on 100% sequence homology)
• Applications: Immunohistochemistry, Immunocytochemistry, Immunofluorescence
• Purity: Protein A & Antigen Affinity
• Synonyms: LRP1; Polyclonal Antibody; Anti-LRP1 Antibody; Rabbit Polyclonal; LRP1/CD91 Antibody; Rabbit PAb; Antigen Affinity Purified; low density lipoprotein receptor-related protein 1; Anti-A2mr Antibody; Anti-AI316852 Antibody; Anti-b2b1554Clo Antibody; Anti-CD91 Antibody; Anti-Lrp Antibody; anti-LRP1 antibody

• Host: Rabbit
• Reactivity: Mouse; Predicted to React with: Human (Species predicted to react based on 100% sequence homology)
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Mouse LRP1
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-LRP1 antibody: Immunohistochemistry-Paraffin (IHC-P), Immunocytochemistry (ICC), Immunofluorescence (IF)
• Application Notes: IHC-P: 1:500-1:2000; ICC/IF: 1:300-1:10,000
• Immunogen: A synthetic peptide corresponding to the C-terminus of the Mouse LRP1/CD91
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with a synthetic peptide corresponding to the C-terminus of the Mouse LRP1/CD91, and purified by antigen affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunochemical staining of mouse LRP1 in mouse liver with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).)

Immunohistochemistry (IHC)

(Immunochemical staining of mouse LRP1 in mouse brain with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).)

Immunofluorescence (IF)

(Immunofluorescence staining of LRP1 in Hela cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS,blocked with 10% serum, and incubated with rabbit anti-human LRP1 polyclonal antibody (1:1000) at 4 degree C overnight. Then cells were stained with the Alexa Fluor488-conjugated Goat Anti-rabbit IgG secondary antibody (green).Positive staining was localized to cytoplasm and nucleus.)

Related Product Information for anti-LRP1 antibody

Low-density lipoprotein receptor-related protein 1 (LRP1), also known as alpha-2-macroglobulin receptor (A2MR), apolipoprotein E receptor (APOER), or cluster of differentiation 91 (CD91), is an endocytic receptor involved in several cellular processes. LRP1/CD91 is a member of the cluster of differentiation (CD) system. The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alters the behavior of the cell. Some CD proteins do not take part in the cell signal process but have other functions such as cell adhesion. LRP1/CD91 is involved in endocytosis and phagocytosis of apoptotic cells and is required for early embryonic development. LRP1/CD91 is also involved in cellular lipid homeostasis, the plasma clearance of chylomicron remnants, activated LRPAP1 (alpha 2-macroglobulin), and the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. LRP1/CD91 May modulate cellular events, such as APP metabolism kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission need the involvement of LRP1/CD91.

Product Categories/Family for anti-LRP1 antibody

Serine Proteases and Regulators

References

Su HP, et al. (2002) Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP). J Biol Chem. 277(14): 11772-9.Chen JS, et al. (2010) Secreted heat shock protein 90alpha induces colorectal cancer cell invasion through CD91/LRP-1 and NF-kappaB-mediated integrin alphaV expression. J Biol Chem. 285(33): 25458-66.Dasgupta S, et al. (2008) Factor VIII bypasses CD91/LRP for endocytosis by dendritic cells leading to T-cell activation. Haematologica. 93(1): 83-9.

NCBI and Uniprot Product Information

• NCBI GI #: 124494256
• NCBI GeneID: 16971
• NCBI Accession #: NP_032538.2
• NCBI GenBank Nucleotide #: NM_008512.2
• UniProt Accession #: Q91ZX7; Q61291; Q920Y4
• Molecular Weight: 504,742 Da
• NCBI Official Full Name: prolow-density lipoprotein receptor-related protein 1
• NCBI Official Synonym Full Names: low density lipoprotein receptor-related protein 1
• NCBI Official Symbol: Lrp1
• NCBI Official Synonym Symbols: Lrp; A2mr; CD91; AI316852; b2b1554Clo
• NCBI Protein Information: prolow-density lipoprotein receptor-related protein 1
• UniProt Protein Name: Prolow-density lipoprotein receptor-related protein 1
• Protein Family: Low-density lipoprotein receptor-related protein
• UniProt Gene Name: Lrp1
• UniProt Synonym Gene Names: LRP-1; A2MR; LRP-85; LRP-515; LRPICD

Uniprot Description

Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission.