Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Rabbit anti-Mouse Low Density Lipoprotein Receptor Related Protein 1 Polyclonal Antibody | anti-LRP1 antibody
Polyclonal Antibody to Low Density Lipoprotein Receptor Related Protein 1 (LRP1)
MSPILGYWKI KGLVQPTRLL LEYLEEKYEE HLYERDEGDK WRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD GSTSGSGHHH HHHSAGLVPR GSTAIGMKET AAAKFERQHM DSPDLGTGGG SGIEGRGSMG YRGSEF-KVFF TDYGQIPKVE RCDMDGQNRT KLVDSKIVFP HGITLDLVSR LVYWADAYLD YIEVVDYEGK
Immunohistochemistry: 5-20ug/mL;1:25-100
Immunocytochemistry: 5-20ug/mL;1:25-100
Optimal working dilutions must be determined by end user.
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin- embedded testis tissue))
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin- embedded testis tissue))
NCBI and Uniprot Product Information
Uniprot Description
LRP1: a receptor involved in endocytosis, phagocytosis of apoptotic cells, and neural signaling. Modulates cellular events including APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling and neurotransmission. Involved in the plasma clearance of chylomicron remnants and activated alpha 2-macroglobulin, as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Plays a fundamental role in cellular signaling pathways in the brain. Mediates neural NMDA gating via a complex of LRP1, PSD-95 and NMDAR. A type I membrane protein. After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus. Most abundant in liver, brain and lung.
Protein type: Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.
Chromosomal Location of Human Ortholog: 10|10 D3
Cellular Component: basolateral plasma membrane; cell soma; clathrin-coated pit; clathrin-coated vesicle; cytoplasm; cytosol; dendrite; early endosome; endosome; focal adhesion; integral component of membrane; integral component of plasma membrane; lysosomal membrane; membrane; nucleolus; nucleus; perinuclear region of cytoplasm; plasma membrane; receptor complex
Molecular Function: alpha-2 macroglobulin receptor activity; apolipoprotein binding; calcium ion binding; clathrin heavy chain binding; metal ion binding; protease binding; protein binding; protein complex binding; RNA binding
Biological Process: apoptotic cell clearance; astrocyte activation during immune response; cardiac septum development; cell proliferation; cellular response to amyloid-beta; cholesterol metabolic process; endocytosis; multicellular organism development; negative regulation of neuron apoptosis; negative regulation of neuron projection development; negative regulation of platelet-derived growth factor receptor-beta signaling pathway; negative regulation of smooth muscle cell migration; negative regulation of Wnt signaling pathway; positive regulation of amyloid-beta clearance; positive regulation of cell death; positive regulation of cholesterol efflux; positive regulation of endocytosis; positive regulation of lipid transport; positive regulation of lysosomal protein catabolic process; positive regulation of protein binding; positive regulation of protein catabolic process; positive regulation of protein transport; protein kinase C-activating G-protein coupled receptor signaling pathway; receptor-mediated endocytosis; regulation of actin cytoskeleton organization; regulation of cholesterol transport; regulation of phospholipase A2 activity; regulation of protein metabolic process; transcytosis
Research Articles on LRP1
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Product Notes
The LRP1 lrp1 (Catalog #AAA2026106) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Low Density Lipoprotein Receptor Related Protein 1 (LRP1) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Low Density Lipoprotein Receptor Related Protein 1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA). Western blotting: 0.2-2ug/mL;1:250-2500 Immunohistochemistry: 5-20ug/mL;1:25-100 Immunocytochemistry: 5-20ug/mL;1:25-100 Optimal working dilutions must be determined by end user. . Researchers should empirically determine the suitability of the LRP1 lrp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with two N-terminal Tags, His-tag and GST-tag and its sequence is listed below. MSPILGYWKI KGLVQPTRLL LEYLEEKYEE HLYERDEGDK WRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD GSTSGSGHHH HHHSAGLVPR GSTAIGMKET AAAKFERQHM DSPDLGTGGG SGIEGRGSMG YRGSEF-KVF F TDYGQIPKVE RCDMDGQNRT KLVDSKIVFP HGITLDLVSR LVYWADAYLD YIEVVDYEGK. It is sometimes possible for the material contained within the vial of "Low Density Lipoprotein Receptor Related Protein 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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