Western Blot (WB)
(LRFN2 Antibody (C-term) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the LRFN2 antibody detected the LRFN2 protein (arrow).)
Rabbit anti-Human LRFN2 Polyclonal Antibody | anti-Lrfn2 antibody
LRFN2, CT (LRFN2, KIAA1246, SALM1, Leucine-rich repeat and fibronectin type-III domain-containing protein 2, Synaptic adhesion-like molecule 1)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Western Blot (WB)
(LRFN2 Antibody (C-term) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the LRFN2 antibody detected the LRFN2 protein (arrow).)
Western Blot (WB)
(LRFN2 Antibody (C-term) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the LRFN2 antibody detected the LRFN2 protein (arrow).)
NCBI and Uniprot Product Information
Uniprot Description
Function: Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 and GRIN2A
By similarity. May play a role in redistributing DLG4 to the cell periphery. Ref.5
Subunit structure: Forms heteromeric complexes with LRFN1, LRFN3, LRFN4 and LRFN5. Can form homomeric complexes, but not across cell junctions
By similarity. Interacts with DLG4. Directly interacts with DLG1, DLG2 and DLG3
By similarity. Directly interacts with 2 NMDA receptor subunits GRIN1 and GRIN2A
By similarity. Ref.5
Subcellular location: Membrane; Single-pass type I membrane protein. Cell junction › synapse. Cell junction › synapse › postsynaptic cell membrane
By similarity Ref.5.
Tissue specificity: Predominantly expressed in the brain, with a weak, but broad expression in the cerebral cortex and diencephalic nuclei. Strongly expressed in both the pyramidal layer and the dentate gyrus of the hippocampus. Also detected in other parts of the central nervous system, including the olfactory bulb, pons, cerebellum, and medulla oblongata, as well as in the peripheral nervous system, such as the ganglia of cranial nerves and the dorsal root ganglion during gestation. Ref.5
Developmental stage: Expression starts around 11.5-12.5 dpc. At 11.5 dpc, detected in the outer layer of the telencephalic vesicles. This pattern of expression continues until 17.5 dpc with expression in the cortical plate, but not in the inner layer of the cerebral cortex, including subplate, ventricular zone, and subventricular zone. As also detected in the hippocampus, amygdala and widely in diencephalic nuclei. Ref.5
Domain: The PDZ-binding motif is required for cell surface expression, neurite outgrowth promotion and interaction with DLG1, DLG3 and DLG4
By similarity.
Post-translational modification: Glycosylated. Ref.5
Sequence similarities: Belongs to the LRFN family.Contains 1 fibronectin type-III domain.Contains 1 Ig-like (immunoglobulin-like) domain.Contains 7 LRR (leucine-rich) repeats.Contains 1 LRRCT domain.Contains 1 LRRNT domain.
Sequence caution: The sequence BAC65758.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
Research Articles on Lrfn2
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Product Notes
The Lrfn2 lrfn2 (Catalog #AAA649773) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The LRFN2, CT (LRFN2, KIAA1246, SALM1, Leucine-rich repeat and fibronectin type-III domain-containing protein 2, Synaptic adhesion-like molecule 1) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's LRFN2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in Western Blot, ELISA Dilution: ELISA: 1:1,000 Western Blot: 1:100-500. Researchers should empirically determine the suitability of the Lrfn2 lrfn2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LRFN2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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