Rabbit LRFN2 Polyclonal Antibody | anti-LRFN2 antibody

LRFN2 Antibody

Cat. Num. AAA151564

• Gene Names: LRFN2; SALM1; FIGLER2; KIAA1246
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: LRFN2 Antibody is affinity chromatography purified via peptide column.
• Synonyms: LRFN2; Polyclonal Antibody; LRFN2 Antibody; SALM1; FIGLER2; KIAA1246; Leucine-rich repeat and fibronectin type-III domain-containing protein 2; Synaptic adhesion-like molecule 1; leucine rich repeat and fibronectin type III domain containing 2; anti-LRFN2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: At least two isoforms of LRFN2 are known to exist. This antibody is predicted to not cross-react with other members of the LRFN family.
• Purity/Purification: LRFN2 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 789

• Applicable Applications for anti-LRFN2 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: LRFN2 antibody can be used for detection of LRFN2 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.
• Conjugate: Unconjugated
• Immunogen: LRFN2 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human LRFN2.
• Buffer: LRFN2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: LRFN2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of LRFN2 in rat brain lysate with LRFN2 antibody at (A) 1 and (B) 2 μg/mL.)

Immunohistochemistry (IHC)

(Immunohistochemistry of LRFN2 in mouse brain tissue with LRFN2 antibody at 2.5 μg/mL.)

Immunofluorescence (IF)

(Immunofluorescence of LRFN2 in mouse brain tissue with LRFN2 antibody at 20 μg/mL.)

Western Blot (WB)

(Western blot analysis of LRFN2 expression in mouse brain tissue lysate with LRFN2 antibody at 1 μg/ml.)

Related Product Information for anti-LRFN2 antibody

LRFN2 Antibody: LRFN2 is one of a family of five transmembrane glycoproteins that are highly expressed in neuronal tissues. LRFN proteins share leucine-rich repeat (LRR)-immunoglobulin-like (Ig)-fibronectin type III (Fn)-transmembrane domain structure with other members of the LRR-Ig-Fn protein superfamily such as the Slitrk family of proteins. Expression of LRFN1, -3, and -4 mRNA was detected in embryonic neuronal cells, while Lrfn2 and Lrfn5 expression was primarily restricted to more mature cells. LRFN1, -2, and -4 bound to PDZ domains of postsynaptic PSD95, re-distributing PSD95 to the cell periphery. It has been suggested that the Lrfn proteins play a role in the developing and/or mature vertebrate nervous system.

NCBI and Uniprot Product Information

• NCBI GI #: 62286951
• NCBI GeneID: 57497
• UniProt Accession #: Q9ULH4; Q5SYP9; A5PKU3
• Molecular Weight: 84,731 Da
• NCBI Official Full Name: Leucine-rich repeat and fibronectin type-III domain-containing protein 2
• NCBI Official Synonym Full Names: leucine rich repeat and fibronectin type III domain containing 2
• NCBI Official Symbol: LRFN2
• NCBI Official Synonym Symbols: SALM1; FIGLER2; KIAA1246
• NCBI Protein Information: leucine-rich repeat and fibronectin type-III domain-containing protein 2; synaptic adhesion-like molecule 1; fibronectin type III, immunoglobulin and leucine rich repeat domains 2
• UniProt Protein Name: Leucine-rich repeat and fibronectin type-III domain-containing protein 2
• Protein Family: Leucine-rich repeat and fibronectin type-III domain-containing protein
• UniProt Gene Name: LRFN2
• UniProt Synonym Gene Names: KIAA1246; SALM1
• UniProt Entry Name: LRFN2_HUMAN

Uniprot Description

LRFN2: Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 and GRIN2A. May play a role in redistributing DLG4 to the cell periphery. Belongs to the LRFN family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.2-p21.1

Cellular Component: postsynaptic membrane; integral to membrane; cell junction