Rabbit anti-Human LRFN2 Polyclonal Antibody | anti-LRFN2 antibody

LRFN2, CT (LRFN2, KIAA1246, SALM1, Leucine-rich repeat and fibronectin type-III domain-containing protein 2, Synaptic adhesion-like molecule 1) (Biotin)

Cat. Num. AAA6316880

• Gene Names: LRFN2; SALM1; FIGLER2; KIAA1246
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: LRFN2; Polyclonal Antibody; CT (LRFN2; KIAA1246; SALM1; Leucine-rich repeat and fibronectin type-III domain-containing protein 2; Synaptic adhesion-like molecule 1) (Biotin); Synaptic adhesion-like molecule 1; anti-LRFN2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-LRFN2 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: LRFN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 629-659 amino acids from the C-terminal region of human LRFN2.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(LRFN2 Antibody (C-term) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the LRFN2 antibody detected the LRFN2 protein (arrow).)

Related Product Information for anti-LRFN2 antibody

LRFN2 promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 and GRIN2A. May play a role in redistributing DLG4 to the cell periphery (By similarity).

Product Categories/Family for anti-LRFN2 antibody

Antibodies; Fibronectin

References

Rose, J. Phd, et al. Mol. Med. (2010). In press: Morimura, N., et al. Gene 380(2):72-83(2006). Wang, C.Y., et al. J. Neurosci. 26(8):2174-2183(2006). Mungall, A.J., et al. Nature 425(6960):805-811(2003).

NCBI and Uniprot Product Information

• NCBI GI #: 55741571
• NCBI GeneID: 57497
• NCBI Accession #: NP_065788.1
• NCBI GenBank Nucleotide #: NM_020737.1
• UniProt Accession #: Q9ULH4; Q5SYP9; A5PKU3
• Molecular Weight: 84,731 Da
• NCBI Official Full Name: leucine-rich repeat and fibronectin type-III domain-containing protein 2
• NCBI Official Synonym Full Names: leucine rich repeat and fibronectin type III domain containing 2
• NCBI Official Symbol: LRFN2
• NCBI Official Synonym Symbols: SALM1; FIGLER2; KIAA1246
• NCBI Protein Information: leucine-rich repeat and fibronectin type-III domain-containing protein 2; synaptic adhesion-like molecule 1; fibronectin type III, immunoglobulin and leucine rich repeat domains 2
• UniProt Protein Name: Leucine-rich repeat and fibronectin type-III domain-containing protein 2
• Protein Family: Leucine-rich repeat and fibronectin type-III domain-containing protein
• UniProt Gene Name: LRFN2
• UniProt Synonym Gene Names: KIAA1246; SALM1
• UniProt Entry Name: LRFN2_HUMAN

Uniprot Description

LRFN2: Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 and GRIN2A. May play a role in redistributing DLG4 to the cell periphery. Belongs to the LRFN family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.2-p21.1

Cellular Component: postsynaptic membrane; integral to membrane; cell junction