Rabbit IKK Gamma Polyclonal Antibody | anti-IKBKG antibody

Rabbit anti IKK Gamma

Cat. Num. AAA225122

• Gene Names: IKBKG; IP; IP1; IP2; FIP3; IKKG; IPD2; NEMO; FIP-3; Fip3p; IMD33; AMCBX1; IKKAP1; ZC2HC9; IKK-gamma
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified whole serum by affinity chromatography.
• Synonyms: IKK Gamma; Polyclonal Antibody; Rabbit anti IKK Gamma; IKK Gamma Antibody; anti-IKBKG antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified whole serum by affinity chromatography.
• Form/Format: Liquid in phosphate buffered saline with 0.02% sodium azide, 50% glycerol.
• Sequence Length: 419

• Applicable Applications for anti-IKBKG antibody: Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
• Application Notes: IHC-Paraffin: 1:50-1:100; WB: 1:500-1:2000
• Immunogen: Recombinant human IKK gamma
• Preperation: Antiserum to IKK gamma was raised by repeated immunization of rabbits with highly purified antigen.
• Preparation and Storage: Store at -20 degree C.; Storage in frost-free freezers is not recommended. This product should be stored undiluted.; Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 12 months from date of despatch

Western Blot (WB)

(Western blot analysis of cell and tissue lysates using Rabbit anti IKK gamma antibody)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human liver cancer using Rabbit anti IKK gamma antibody at a dilution of 1/100)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded rat heart using Rabbit anti IKK gamma antibody)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded rat brain using Rabbit anti IKK gamma antibody)

Related Product Information for anti-IKBKG antibody

Rabbit anti IKK gamma antibody recognizes IKK gamma, also known as NF-kappa-B essential modulator (NEMO), IKBKG and inhibitor of nuclear factor kappa-B kinase subunit gamma. IKK gamma is the regulatory subunit of the inhibitor of IkB kinase complex which activates NF-kappa-B resulting in expression of genes involved in inflammation, immunity, cell survival, and other pathways.

NCBI and Uniprot Product Information

• NCBI GI #: 6685695
• NCBI GeneID: 8517
• UniProt Accession #: Q9Y6K9; Q7LBY6; Q7Z7F1
• Molecular Weight: 36,953 Da
• NCBI Official Full Name: NF-kappa-B essential modulator
• NCBI Official Synonym Full Names: inhibitor of nuclear factor kappa B kinase subunit gamma
• NCBI Official Symbol: IKBKG
• NCBI Official Synonym Symbols: IP; IP1; IP2; FIP3; IKKG; IPD2; NEMO; FIP-3; Fip3p; IMD33; AMCBX1; IKKAP1; ZC2HC9; IKK-gamma
• NCBI Protein Information: NF-kappa-B essential modulator
• UniProt Protein Name: NF-kappa-B essential modulator
• UniProt Gene Name: IKBKG
• UniProt Synonym Gene Names: FIP3; NEMO; NEMO; IKKAP1; I-kappa-B kinase subunit gamma; IKK-gamma; IKKG; IkB kinase subunit gamma

NCBI Description

This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [provided by RefSeq, Mar 2016]

Uniprot Description

Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination.