Western Blot (WB)
(Anti-LIF antibody, MBS175620, Western blottingAll lanes: Anti LIF (MBS175620) at 0.5ug/mlLane 1: Rat Intestine Tissue Lysate at 50ugLane 2: Rat Brain Tissue Lysate at 50ugLane 3: Rat Spleen Tissue Lysate at 50ugLane 4: Rat Thymus Tissue Lysate at 50ugLane 5: Mouse Brain Tissue Lysate at 50ugLane 6: Mouse Kidney Tissue Lysate at 50ugLane 7: Mouse Liver Tissue Lysate at 50ugPredicted bind size: 22KDObserved bind size: 40KD )
Rabbit anti-Mouse, Rat LIF Polyclonal Antibody | anti-LIF antibody
Anti-LIF antibody
Western Blot (WB)
(Anti-LIF antibody, MBS175620, Western blottingAll lanes: Anti LIF (MBS175620) at 0.5ug/mlLane 1: Rat Intestine Tissue Lysate at 50ugLane 2: Rat Brain Tissue Lysate at 50ugLane 3: Rat Spleen Tissue Lysate at 50ugLane 4: Rat Thymus Tissue Lysate at 50ugLane 5: Mouse Brain Tissue Lysate at 50ugLane 6: Mouse Kidney Tissue Lysate at 50ugLane 7: Mouse Liver Tissue Lysate at 50ugPredicted bind size: 22KDObserved bind size: 40KD )
Western Blot (WB)
(Anti-LIF antibody, MBS175620, Western blottingAll lanes: Anti LIF (MBS175620) at 0.5ug/mlLane 1: Rat Intestine Tissue Lysate at 50ugLane 2: Rat Brain Tissue Lysate at 50ugLane 3: Rat Spleen Tissue Lysate at 50ugLane 4: Rat Thymus Tissue Lysate at 50ugLane 5: Mouse Brain Tissue Lysate at 50ugLane 6: Mouse Kidney Tissue Lysate at 50ugLane 7: Mouse Liver Tissue Lysate at 50ugPredicted bind size: 22KDObserved bind size: 40KD )
Background: LIF is a pleiotropic cytokine produced at the maternal-fetal interface which has been shown to play an essential role in implantation in mice. LIF is produced in high amounts by the human endometrium and the trophoblast itself, and LIF receptors are present on cytotrophoblast cells. LIF could, thus, play a role in modulating HLA-G production and immune tolerance at the maternal-fetal interface. The gene maps to 22q11-q12.2, between the Philadelphia translocation BCR gene and the breakpoint of the translocation in cell line GM2324 at 22q12.2.
NCBI and Uniprot Product Information
Uniprot Description
LIF: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes. Belongs to the LIF/OSM family.
Protein type: Secreted; Secreted, signal peptide
Cellular Component: extracellular space; cytoplasm; extracellular region
Molecular Function: growth factor activity; leukemia inhibitory factor receptor binding; cytokine activity; receptor binding
Biological Process: transcription from RNA polymerase II promoter; maternal process involved in pregnancy; leukemia inhibitory factor signaling pathway; negative regulation of hormone secretion; tyrosine phosphorylation of Stat3 protein; decidualization; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of adrenocorticotropic hormone secretion; negative regulation of cell proliferation; astrocyte differentiation; positive regulation of MAPKKK cascade; regulation of cell differentiation; positive regulation of cell proliferation; negative regulation of meiosis; positive regulation of macrophage differentiation; muscle morphogenesis; positive regulation of astrocyte differentiation; positive regulation of peptidyl-serine phosphorylation of STAT protein; organ regeneration; stem cell maintenance; stem cell differentiation; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of tyrosine phosphorylation of Stat1 protein; negative regulation of angiogenesis; retina development in camera-type eye; neuron development; immune response; positive regulation of transcription from RNA polymerase II promoter; blood vessel remodeling; alveolus development; embryo implantation; lung development
Research Articles on LIF
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Product Notes
The LIF lif (Catalog #AAA175620) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-LIF antibody reacts with Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's LIF can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the LIF lif for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LIF, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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