Rabbit anti-Human LCP2 Polyclonal Antibody | anti-LCP2 antibody

LCP2 Polyclonal Antibody

Cat. Num. AAA9133545

• Gene Names: LCP2; SLP76; SLP-76
• Reactivity: Human
• Applications: Immunofluorescence
• Purity: Affinity Purification
• Synonyms: LCP2; Polyclonal Antibody; LCP2 Polyclonal Antibody; SLP-76; SLP76; anti-LCP2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification
• Sequence: KPPLPPTTERHERSSPLPGKKPPVPKHGWGPDRRENDEDDVHQRPLPQPALLPMSSNTFPSRSTKPSPMNPLPSSHMPGAFSESNSSFPQSASLPPYFSQGPSNRPPIRAEGRNFPLPLPNKPRPPSPAEEENSLNEEWYVSYITRPEAEAALRKINQDGTFLVRDSSKKTTTNPYVLMVLYKDKVYNIQIRYQKESQVYLLGTGLRGKEDFLSVSDIIDYFRKMPLLLIDGKNRGSRYQCTLTHAAGYP
• Sequence Length: 533

• Applicable Applications for anti-LCP2 antibody: Immunofluorescence (IF)
• Application Notes: IF: 1:50 - 1:200
• Immunogen: Recombinant protein of human LCP2
• Immunogen Species: Human
• Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Cellular Location: Cytoplasm
• Preparation and Storage: Store at -20 degree C. Avoid freeze / thaw cycles.

Immunofluorescence (IF)

(Immunofluorescence analysis of HeLa cells using LCP2 antibody. Blue: DAPI for nuclear staining.)

Related Product Information for anti-LCP2 antibody

SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.

Product Categories/Family for anti-LCP2 antibody

Polyclonal Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 5031855
• NCBI GeneID: 3937
• NCBI Accession #: NP_005556.1
• NCBI GenBank Nucleotide #: NM_005565.4
• UniProt Accession #: Q13094; Q53XV4; A8KA25
• Molecular Weight: 60kDa
• NCBI Official Full Name: lymphocyte cytosolic protein 2
• NCBI Official Synonym Full Names: lymphocyte cytosolic protein 2
• NCBI Official Symbol: LCP2
• NCBI Official Synonym Symbols: SLP76; SLP-76
• NCBI Protein Information: lymphocyte cytosolic protein 2
• UniProt Protein Name: Lymphocyte cytosolic protein 2
• Protein Family: Larval cuticle protein
• UniProt Gene Name: LCP2
• UniProt Synonym Gene Names: SLP76

NCBI Description

This gene encodes an adapter protein that acts as a substrate of the T cell antigen receptor (TCR)-activated protein tyrosine kinase pathway. The encoded protein associates with growth factor receptor bound protein 2, and is thought to play a role TCR-mediated intracellular signal transduction. A similar protein in mouse plays a role in normal T-cell development and activation. Mice lacking this gene show subcutaneous and intraperitoneal fetal hemorrhaging, dysfunctional platelets and impaired viability. [provided by RefSeq, Nov 2016]

Uniprot Description

Involved in T-cell antigen receptor mediated signaling.