Western Blot (WB)
(Western blot analysis of LASS6 in rat brain tissue lysate with LASS6 antibody at (A) 1 and (B) 2 μg/mL.)
Rabbit LASS6 Polyclonal Antibody | anti-LASS6 antibody
LASS6 Antibody
Gene Names
CERS6; CERS5; LASS6
Reactivity
Human, Mouse, Rat
Applications
ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
Purity
LASS6 Antibody is affinity chromatography purified via peptide column.
Synonyms
LASS6; Polyclonal Antibody; LASS6 Antibody; CERS5; Ceramide synthase 6; LAG1 longevity assurance homolog 6; CerS6; LAG1 homolog; ceramide synthase 6; anti-LASS6 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
At least two isoforms of LASS6 are known to exist. This antibody is predicted not to cross-react with LASS5.
Purity/Purification
LASS6 Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (varies by lot)
Sequence Length
392
Applicable Applications for anti-LASS6 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes
LASS6 antibody can be used for detection of LASS6 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.
Conjugate
Unconjugated
Immunogen
LASS6 antibody was raised against a 13 amino acid synthetic peptide near the amino terminus of the human LASS6.
Buffer
LASS6 Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
LASS6 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Western Blot (WB)
(Western blot analysis of LASS6 in rat brain tissue lysate with LASS6 antibody at (A) 1 and (B) 2 μg/mL.)
Western Blot (WB)
(Western blot analysis of LASS6 in rat brain tissue lysate with LASS6 antibody at (A) 1 and (B) 2 μg/mL.)
Immunohistochemistry (IHC)
(Immunohistochemistry of LASS6 in mouse brain tissue with LASS6 antibody at 2.5 μg/mL.)
Immunohistochemistry (IHC)
(Immunohistochemistry of LASS6 in mouse brain tissue with LASS6 antibody at 2.5 μg/mL.)
Immunofluorescence (IF)
(Immunofluorescence of LASS6 in Mouse Brain cells with LASS6 antibody at 5 μg/mL.)
Immunofluorescence (IF)
(Immunofluorescence of LASS6 in Mouse Brain cells with LASS6 antibody at 5 μg/mL.)
Related Product Information for anti-LASS6 antibody
LASS6 Antibody: The LASS (longevity assurance homolog) family members represent a subgroup of the homeobox gene family and are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1-6) and all are involved in ceramide synthesis during cell growth regulation and cancer differentiation. Like the highly homologous LASS5, LASS6 is also an endoplasmic reticulum, multi-pass membrane protein. LASS6 is also involved in the synthesis of C14, C16 and C18-ceramide, but shows a preference for unsaturated fatty acids. LASS6 is broadly expressed in a wide range of tissues and microarray data suggests that it may play a role in cancer differentiation and early embryonic development.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
45,794 Da
NCBI Official Full Name
LASS6 protein
NCBI Official Synonym Full Names
ceramide synthase 6
NCBI Official Symbol
CERS6
NCBI Official Synonym Symbols
CERS5; LASS6
NCBI Protein Information
ceramide synthase 6; longevity assurance homolog 6; LAG1 homolog, ceramide synthase 6
UniProt Protein Name
Ceramide synthase 6
UniProt Gene Name
CERS6
UniProt Synonym Gene Names
LASS6; CerS6
UniProt Entry Name
CERS6_HUMAN
Uniprot Description
LASS6: May be involved in sphingolipid synthesis or its regulation.
Protein type: DNA-binding; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 2q24.3
Cellular Component: endoplasmic reticulum membrane; nuclear membrane; membrane; endoplasmic reticulum; integral to membrane
Molecular Function: DNA binding; sphingosine N-acyltransferase activity
Biological Process: sphingolipid metabolic process; sphingolipid biosynthetic process; ceramide biosynthetic process
Research Articles on LASS6
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Product Notes
The LASS6 cers6 (Catalog #AAA150712) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The LASS6 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's LASS6 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF). LASS6 antibody can be used for detection of LASS6 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL. Researchers should empirically determine the suitability of the LASS6 cers6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LASS6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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