Western Blot/Blotting
(Western blot analysis using LAG1 longevity assurance homolog 6 at 6ug/ml on human Duodenum lysate 14 ug/lane. Lane A] antibody alone, Lane B] antibody plus 50 ug blocking peptide , Lane C] conjugate alone. Visualized using Pierce West Femto substrate system. Anti Rabbit secondary used at 1:3.5K dilution . Exposure for 1.5 minutes)
Rabbit anti-Human Lass6 Polyclonal Antibody | anti-Lass6 antibody
Lass6
Gene Names
CERS6; CERS5; LASS6
Reactivity
Human
Applications
Western Blot
Purity
Antigen Immunoaffiinity Purification
Synonyms
Lass6; Polyclonal Antibody; LAG1 longevity assurance homolog 6; anti-Lass6 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Purity/Purification
Antigen Immunoaffiinity Purification
Form/Format
Provided as solution in phosphate buffered saline with 0.08% sodium azide
Sequence Length
392
Applicable Applications for anti-Lass6 antibody
Western Blot (WB)
Immunogen
Synthetic peptide dervied from human Lass6 protein
Positive Control
Widely expressed. Expressed in kidney, liver, brain, heart, placenta and lung.
Preparation and Storage
Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles
Western Blot/Blotting
(Western blot analysis using LAG1 longevity assurance homolog 6 at 6ug/ml on human Duodenum lysate 14 ug/lane. Lane A] antibody alone, Lane B] antibody plus 50 ug blocking peptide , Lane C] conjugate alone. Visualized using Pierce West Femto substrate system. Anti Rabbit secondary used at 1:3.5K dilution . Exposure for 1.5 minutes)
Western Blot/Blotting
(Western blot analysis using LAG1 longevity assurance homolog 6 at 6ug/ml on human Duodenum lysate 14 ug/lane. Lane A] antibody alone, Lane B] antibody plus 50 ug blocking peptide , Lane C] conjugate alone. Visualized using Pierce West Femto substrate system. Anti Rabbit secondary used at 1:3.5K dilution . Exposure for 1.5 minutes)
Related Product Information for anti-Lass6 antibody
Longevity assurance genes (LAGs) represent a subgroup of the homeobox gene family. Five mammalian homologs have been reported, and the corresponding proteins have previously been investigated with respect to their key role in ceramide synthesis. However, members of the LAG family have been shown to be involved in cell growth regulation and cancer differentiation. May be involved in sphingolipid synthesis or its regulation. Interacts with ATP6V0C, ASGR1, ASGR2 and SLC22A1/OCT1. Localized to nuclear membrane a multi-pass membrane protein, may be expressed on endoplasmic reticulum membrane. Glycosylation on Asn-18 is not necessary for function. Like other LAG family members, the LASS6 protein contained a homeodomain and LAG1 domain. Lass6 displays highest homology to LASS5. The corresponding gene was localized to human chromosome 2q24.3, spanning a rather large genomic region of 318 kb. Sequences in mouse and zebrafish suggested a conservation of LASS6 in vertebrates because the protein and corresponding genomic sequences are highly conserved. LASS6 was shown to be broadly expressed in a wide range of tissues. Recent data suggested a role in cancer differentiation and early embryonic development.
Product Categories/Family for anti-Lass6 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
45 kDa
NCBI Official Full Name
ceramide synthase 6 isoform 1
NCBI Official Synonym Full Names
ceramide synthase 6
NCBI Official Symbol
CERS6
NCBI Official Synonym Symbols
CERS5; LASS6
NCBI Protein Information
ceramide synthase 6; longevity assurance homolog 6; LAG1 homolog, ceramide synthase 6
UniProt Protein Name
Ceramide synthase 6
UniProt Gene Name
CERS6
UniProt Synonym Gene Names
LASS6; CerS5
UniProt Entry Name
CERS6_HUMAN
Uniprot Description
Function: May be involved in sphingolipid synthesis or its regulation
By similarity.
Subcellular location: Nucleus membrane; Multi-pass membrane protein
Potential. Endoplasmic reticulum membrane; Multi-pass membrane protein
By similarity.
Post-translational modification: Glycosylation on Asn-18 is not necessary for function
By similarity.
Sequence similarities: Contains 1 homeobox DNA-binding domain.Contains 1 TLC (TRAM/LAG1/CLN8) domain.
Sequence caution: The sequence AAH30800.2 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.
Research Articles on Lass6
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Product Notes
The Lass6 cers6 (Catalog #AAA396052) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Lass6 reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Lass6 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the Lass6 cers6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Lass6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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