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Immunohistochemistry (IHC) (Immunohistochemistry with Human kidney lysate tissue at an antibody concentration of 5.0ug/ml using anti-LASS2 antibody )

Rabbit LASS2 Polyclonal Antibody | anti-CERS2 antibody

LASS2 antibody - N-terminal region

Gene Names
CERS2; L3; LASS2; SP260; TMSG1
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Applications
Immunohistochemistry, Western Blot
Purity
Affinity Purified
Synonyms
LASS2; Polyclonal Antibody; LASS2 antibody - N-terminal region; anti-CERS2 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Clonality
Polyclonal
Purity/Purification
Affinity Purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Sequence
Synthetic peptide located within the following region: EKTRLRAPPNATLEHFYLTSGKQPKQVEVELLSRQSGLSGRQVERWFRRR
Sequence Length
380
Applicable Applications for anti-CERS2 antibody
Immunohistochemistry (IHC), Western Blot (WB)
Homology
Cow: 86%; Dog: 93%; Guinea Pig: 100%; Horse: 92%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 93%
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human LASS2
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry with Human kidney lysate tissue at an antibody concentration of 5.0ug/ml using anti-LASS2 antibody )

Immunohistochemistry (IHC) (Immunohistochemistry with Human kidney lysate tissue at an antibody concentration of 5.0ug/ml using anti-LASS2 antibody )

Western Blot (WB)

(WB Suggested Anti-LASS2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Human brain)

Western Blot (WB) (WB Suggested Anti-LASS2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Human brain)
Related Product Information for anti-CERS2 antibody
This is a rabbit polyclonal antibody against LASS2. It was validated on Western Blot using a cell lysate as a positive control.

Target Description: LASS2 is a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
45kDa
NCBI Official Full Name
ceramide synthase 2
NCBI Official Synonym Full Names
ceramide synthase 2
NCBI Official Symbol
CERS2
NCBI Official Synonym Symbols
L3; LASS2; SP260; TMSG1
NCBI Protein Information
ceramide synthase 2
UniProt Protein Name
Ceramide synthase 2
Protein Family
UniProt Gene Name
CERS2
UniProt Synonym Gene Names
LASS2; TMSG1; CerS2
UniProt Entry Name
CERS2_HUMAN

NCBI Description

This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis.

Subunit structure: Interacts with ATP6V0C, ASGR1, ASGR2 and SLC22A1/OCT1. Interacts with ELOV1, HSD17B12 and TECR. Ref.1 Ref.15

Subcellular location: Nucleus membrane; Multi-pass membrane protein

Potential. Endoplasmic reticulum membrane; Multi-pass membrane protein

By similarity.

Tissue specificity: Expressed in kidney, liver, brain, heart, placenta and lung. Ref.1

Sequence similarities: Contains 1 homeobox DNA-binding domain.Contains 1 TLC (TRAM/LAG1/CLN8) domain.

Sequence caution: The sequence BAA91505.1 differs from that shown. Reason: Erroneous initiation.

Research Articles on CERS2

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Product Notes

The CERS2 cers2 (Catalog #AAA3201046) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The LASS2 antibody - N-terminal region reacts with Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's LASS2 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Western Blot (WB). Researchers should empirically determine the suitability of the CERS2 cers2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: EKTRLRAPPN ATLEHFYLTS GKQPKQVEVE LLSRQSGLSG RQVERWFRRR. It is sometimes possible for the material contained within the vial of "LASS2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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