Western Blot (WB)
Mouse anti-Human LAG1 longevity assurance homolog 2, LASS2 Polyclonal Antibody | anti-LASS2 antibody
Anti-LAG1 longevity assurance homolog 2, LASS2 antibody
Gene Names
CERS2; L3; LASS2; SP260; TMSG1
Reactivity
Human
Applications
Western Blot, Immunohistochemistry, Immunocytochemistry
Purity
Protein A or Protein G purified
Synonyms
LAG1 longevity assurance homolog 2; LASS2; Polyclonal Antibody; Anti-LAG1 longevity assurance homolog 2; LASS2 antibody; Monoclonal Anti- LAG1 longevity assurance homolog 2; anti-LASS2 antibody
Host
Mouse
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG2b
Clone Number
N39
Purity/Purification
Protein A or Protein G purified
Form/Format
Liquid
Applicable Applications for anti-LASS2 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC)
Application Notes
WB (1:500-1000)
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to the extracellular region of human LASS2.
Storage Buffer
In TBS (pH7.4), 0.5% BSA, 40% Glycerol and 0.05% Sodium Azide
Storage Buffer
In TBS (pH7.4), 0.5% BSA, 40% Glycerol and 0.05% Sodium Azide.
Preparation and Storage
Store at 4 degree C after thawing (1 week). Aliquot and store at -20 degree C for long term (at least one year). Avoid repeated freeze and thaw cycles.
Western Blot (WB)
Western Blot (WB)
Related Product Information for anti-LASS2 antibody
Lass2 (LAG1 longevity assurance homolog 2) is a protein that in humans is encoded by the LASS2 gene.[1] It has sequence similarity to yeast longevity assurance gene 1. And it is highly expressed in liver and kidney, which is very different from the expression of the previously identified human LAG1 homologue LAG1Hs-1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. LASS2 protein was able to inhibit the colony formation of human hepatoma cells in vitro, and it also plays a role in the regulation of cell growth.
References
1. Pan H, Qin WX, Huo KK, Wan DF, Yu Y, Xu ZG, Hu QD, Gu KT, Zhou XM, Jiang HQ, Zhang PP, Huang Y, Li YY, Gu JR (Sep 2001). "Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1". Genomics 77 (1-2): 58-64.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
44,876 Da
NCBI Official Full Name
LAG1 longevity assurance homolog 2 (S. cerevisiae), isoform CRA_a
NCBI Official Synonym Full Names
ceramide synthase 2
NCBI Official Symbol
CERS2
NCBI Official Synonym Symbols
L3; LASS2; SP260; TMSG1
NCBI Protein Information
ceramide synthase 2; LAG1 longevity assurance 2; LAG1 homolog, ceramide synthase 2; tumor metastasis-suppressor gene 1 protein; longevity assurance (LAG1, S. cerevisiae) homolog 2
UniProt Protein Name
Ceramide synthase 2
UniProt Gene Name
CERS2
UniProt Synonym Gene Names
LASS2; TMSG1; CerS2
UniProt Entry Name
CERS2_HUMAN
NCBI Description
This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis.
Subunit structure: Interacts with ATP6V0C, ASGR1, ASGR2 and SLC22A1/OCT1. Interacts with ELOV1, HSD17B12 and TECR. Ref.1 Ref.15
Subcellular location: Nucleus membrane; Multi-pass membrane protein
Potential. Endoplasmic reticulum membrane; Multi-pass membrane protein
By similarity.
Tissue specificity: Expressed in kidney, liver, brain, heart, placenta and lung. Ref.1
Sequence similarities: Contains 1 homeobox DNA-binding domain.Contains 1 TLC (TRAM/LAG1/CLN8) domain.
Sequence caution: The sequence BAA91505.1 differs from that shown. Reason: Erroneous initiation.
Research Articles on LASS2
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Product Notes
The LASS2 cers2 (Catalog #AAA355148) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-LAG1 longevity assurance homolog 2, LASS2 antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's LAG1 longevity assurance homolog 2, LASS2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC). WB (1:500-1000). Researchers should empirically determine the suitability of the LASS2 cers2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LAG1 longevity assurance homolog 2, LASS2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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