Rabbit Kv3.1 Polyclonal Antibody | anti-Kv3.1 antibody

Kv3.1 Polyclonal Antibody

Cat. Num. AAA3005952

• Gene Names: KCNC1; KV4; EPM7; NGK2; KV3.1
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: Kv3.1; Polyclonal Antibody; Kv3.1 Polyclonal Antibody; Potassium voltage-gated channel subfamily C member 1; NGK2; Voltage-gated potassium channel subunit Kv3.1; Voltage-gated potassium channel subunit Kv4; KCNC1; anti-Kv3.1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Kv3.1 polyclonal antibody detects endogenous levels of Kv3.1 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 511

• Applicable Applications for anti-Kv3.1 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: Synthetic peptide, corresponding to amino acids 254-299 of Human Kv3.1.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of Kv3. 1 polyclonal antibody at 1:500 dilutionLane1:Jurkat cell lysateLane2:Raw264. 7 cell lysateLane3:H9C2 cell lysate)

Related Product Information for anti-Kv3.1 antibody

The human voltage-gated potassium (KV) channel KV3.1 gene maps to chromosome 11p15 and encodes a protein that resembles Drosophila Shaw subfamily channel types. KV channels regulate neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. KV channels are multimers that contain channel activity-dependent alpha subunits and modulatory gamma subunits. Neuronal populations in the CNS coexpressing KV3.1 and KV3.3 influence fast repolarization of action potentials and enable neurons to fire repetitively at high frequencies. KV3 genes produce multiple splice variants in the 3' ends of respective transcript, which may influence normal spatial ion permeability of excitable membranes in the brain.

NCBI and Uniprot Product Information

• NCBI GI #: 4826786
• NCBI GeneID: 3746
• NCBI Accession #: NP_004967.1
• NCBI GenBank Nucleotide #: NP_004967.1
• UniProt Accession #: P48547
• Molecular Weight: ~ 58kDa
• NCBI Official Full Name: potassium voltage-gated channel subfamily C member 1 isoform 2
• NCBI Official Synonym Full Names: potassium voltage-gated channel subfamily C member 1
• NCBI Official Symbol: KCNC1
• NCBI Official Synonym Symbols: KV4; EPM7; NGK2; KV3.1
• NCBI Protein Information: potassium voltage-gated channel subfamily C member 1
• UniProt Protein Name: Potassium voltage-gated channel subfamily C member 1
• UniProt Gene Name: KCNC1
• UniProt Entry Name: KCNC1_HUMAN

NCBI Description

This gene encodes a member of a family of integral membrane proteins that mediate the voltage-dependent potassium ion permeability of excitable membranes. Alternative splicing is thought to result in two transcript variants encoding isoforms that differ at their C-termini. These isoforms have had conflicting names in the literature: the longer isoform has been called both "b" and "alpha", while the shorter isoform has been called both "a" and "beta" (PMIDs 1432046, 12091563). [provided by RefSeq, Oct 2014]

Uniprot Description

Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

Subunit structure: Heteromultimer with KCNG3, KCNG4 and KCNV2.

Subcellular location: Membrane; Multi-pass membrane protein.

Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.

Sequence similarities: Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.1/KCNC1 sub-subfamily. [View classification]