Western Blot (WB)
(KCNC1 Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the KCNC1 antibody detected the KCNC1 protein (arrow).)
Rabbit KCNC1 Polyclonal Antibody | anti-KCNC1 antibody
KCNC1 Antibody (C-term)
Western Blot (WB)
(KCNC1 Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the KCNC1 antibody detected the KCNC1 protein (arrow).)
Western Blot (WB)
(KCNC1 Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the KCNC1 antibody detected the KCNC1 protein (arrow).)
Immunohistochemistry (IHC)
(KCNC1 Antibody (C-term) (MBS9213313)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of KCNC1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(KCNC1 Antibody (C-term) (MBS9213313)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of KCNC1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
voltage-gated potassium channels and is comprised of four
subfamilies. Based on sequence similarity, this gene is similar to
one of these subfamilies, namely the Shaw subfamily. The protein
encoded by this gene belongs to the delayed rectifier class of
channel proteins and is an integral membrane protein that mediates
the voltage-dependent potassium ion permeability of excitable
membranes. Multiple transcript variants encoding different isoforms
have been inferred for this gene based on orthologous loci.
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Wang, Z., et al. J. Gen. Physiol. 133(4):361-374(2009)
Gutman, G.A., et al. Pharmacol. Rev. 57(4):473-508(2005)
Devaux, J., et al. J. Neurosci. 23(11):4509-4518(2003)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of a family of integral membrane proteins that mediate the voltage-dependent potassium ion permeability of excitable membranes. Alternative splicing is thought to result in two transcript variants encoding isoforms that differ at their C-termini. These isoforms have had conflicting names in the literature: the longer isoform has been called both "b" and "alpha", while the shorter isoform has been called both "a" and "beta" (PMIDs 1432046, 12091563). [provided by RefSeq, Oct 2014]
Uniprot Description
Kv3.1 iso2: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.1/KCNC1 sub-subfamily.
Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 11p15
Cellular Component: voltage-gated potassium channel complex; plasma membrane; integral to membrane; axolemma
Molecular Function: voltage-gated potassium channel activity; kinesin binding; delayed rectifier potassium channel activity
Biological Process: synaptic transmission; potassium ion transport; protein homooligomerization
Disease: Epilepsy, Progressive Myoclonic 7
Research Articles on KCNC1
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Product Notes
The KCNC1 kcnc1 (Catalog #AAA9213313) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 479-508. The KCNC1 Antibody (C-term) reacts with Human (Predicted Reactivity: Mouse) and may cross-react with other species as described in the data sheet. AAA Biotech's KCNC1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the KCNC1 kcnc1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KCNC1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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