Western Blot (WB)
(Western Blot: Sample: Mouse Pancreas lysate; Primary Ab: 1ug/ml Rabbit Anti-Human KLb Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody )
Rabbit anti-Human Klotho Beta (KLb) Polyclonal Antibody | anti-KLb antibody
Polyclonal Antibody to Klotho Beta (KLb)
MGHHHHHHSGSEF-VQGQ FPCDFSWGVT ESVLKPESVA SSPQFSDPHL YVWNATGNRL LHRVEGVRLK TRPAQCTDFV NIKKQLEMLA RMKVTHYRFA LDWASVLPTG NLSAVNRQAL RYYRCVVSEG LKLGIS
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Western Blot (WB)
(Western Blot: Sample: Mouse Pancreas lysate; Primary Ab: 1ug/ml Rabbit Anti-Human KLb Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody )
Western Blot (WB)
(Western Blot: Sample: Mouse Pancreas lysate; Primary Ab: 1ug/ml Rabbit Anti-Human KLb Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody )
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Immunohistochemistry (IHC)
(HE staining on IHC-P; Samples: Human Pancreas Tissue)
Immunohistochemistry (IHC)
(HE staining on IHC-P; Samples: Human Pancreas Tissue)
Immunohistochemistry (IHC)
(HE staining on IHC-P; Samples: Human Kidney Tissue.)
Immunohistochemistry (IHC)
(HE staining on IHC-P; Samples: Human Kidney Tissue.)
NCBI and Uniprot Product Information
Uniprot Description
Klotho beta: Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21. Belongs to the glycosyl hydrolase 1 family. Klotho subfamily.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 4p14
Cellular Component: integral component of plasma membrane; intracellular; plasma membrane
Molecular Function: 1-phosphatidylinositol-3-kinase activity; beta-glucosidase activity; fibroblast growth factor binding; fibroblast growth factor receptor binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; Ras guanyl-nucleotide exchange factor activity
Biological Process: carbohydrate metabolic process; fibroblast growth factor receptor signaling pathway; MAPK cascade; phosphatidylinositol phosphorylation; phosphoinositide-mediated signaling; positive regulation of cell proliferation; positive regulation of GTPase activity; regulation of phosphatidylinositol 3-kinase signaling
Research Articles on KLb
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Product Notes
The KLb klb (Catalog #AAA2004348) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Klotho Beta (KLb) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Klotho Beta (KLb) can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the KLb klb for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below. MGHHHHHHSG SEF-VQGQ FPCDFSWGVT ESVLKPESVA SSPQFSDPHL YVWNATGNRL LHRVEGVRLK TRPAQCTDFV NIKKQLEMLA RMKVTHYRFA LDWASVLPTG NLSAVNRQAL RYYRCVVSEG LKLGIS. It is sometimes possible for the material contained within the vial of "Klotho Beta (KLb), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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