Western Blot (WB)
(Western Blot analysis of KIF22 expression in transfected 293T cell line by KIF22 polyclonal antibody. Lane 1: KIF22 transfected lysate (73.15kD). Lane 2: Non-transfected lysate.)
Mouse anti-Human KIF22 Polyclonal Antibody | anti-KIF22 antibody
KIF22 (Kinesin Family Member 22, KIF-22, Kinesin-like DNA-binding Protein, Kinesin-like Protein 4, KNSL4, KID, Kinesin-like Protein KIF22, OriP Binding Protein, OBP1, OBP2, OBP, Origin of Plasmid DNA Replication Binding Protein)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Dilution: Immunofluorescence: 10ug/ml
Western Blot (WB)
(Western Blot analysis of KIF22 expression in transfected 293T cell line by KIF22 polyclonal antibody. Lane 1: KIF22 transfected lysate (73.15kD). Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of KIF22 expression in transfected 293T cell line by KIF22 polyclonal antibody. Lane 1: KIF22 transfected lysate (73.15kD). Lane 2: Non-transfected lysate.)
Immunofluorescence (IF)
(Immunofluorescence of purified antibody to KIF22 on HeLa cell. [antibody concentration 10ug/ml])
Immunofluorescence (IF)
(Immunofluorescence of purified antibody to KIF22 on HeLa cell. [antibody concentration 10ug/ml])
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the kinesin-like protein family. The family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. The C-terminal half of this protein has been shown to bind DNA. Studies with the Xenopus homolog suggests its essential role in metaphase chromosome alignment and maintenance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Uniprot Description
KIF22: Kinesin family that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA. Defects in KIF22 are the cause of spondyloepimetaphyseal dysplasia with joint laxity, type 2 (SEMDJL2). A bone disease characterized by short stature, distinctive midface retrusion, progressive knee malalignment (genu valgum and/or varum), generalized ligamentous laxity, and mild spinal deformity. Intellectual development is not impaired. Radiographic characteristics include significantly retarded epiphyseal ossification that evolves into epiphyseal dysplasia and precocious osteoarthritis, metaphyseal irregularities and vertical striations, constricted femoral neck, slender metacarpals and metatarsals, and mild thoracolumbar kyphosis or scoliosis with normal or mild platyspondyly. The most distinctive features for differential diagnosis of SEMDJL2 are the slender metacarpals and phalanges and the progressive degeneration of carpal bones; however, these 2 features are evident only in older children and young adults. The soft consistency of cartilage in the airways leads to laryngotracheomalacia with proneness to respiratory obstruction and inspiratory stridor in infancy and childhood. Belongs to the kinesin-like protein family.
Protein type: Motor; Microtubule-binding
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: kinetochore; nucleoplasm; microtubule; kinesin complex; focal adhesion; cytoplasm; spindle; cytosol; nucleus; chromatin
Molecular Function: DNA binding; microtubule binding; ATPase activity; microtubule motor activity; ATP binding
Biological Process: mitosis; sister chromatid cohesion; antigen processing and presentation of exogenous peptide antigen via MHC class II; DNA repair; blood coagulation; mitotic metaphase plate congression; microtubule-based movement
Disease: Spondyloepimetaphyseal Dysplasia With Joint Laxity Type 2
Research Articles on KIF22
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Product Notes
The KIF22 kif22 (Catalog #AAA645204) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The KIF22 (Kinesin Family Member 22, KIF-22, Kinesin-like DNA-binding Protein, Kinesin-like Protein 4, KNSL4, KID, Kinesin-like Protein KIF22, OriP Binding Protein, OBP1, OBP2, OBP, Origin of Plasmid DNA Replication Binding Protein) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's KIF22 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunofluorescence (IF). Suitable for use in Immunofluorescence and Western Blot. Dilution: Immunofluorescence: 10ug/ml. Researchers should empirically determine the suitability of the KIF22 kif22 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MAAGGSTQQR RREMAAASAA AISGAGRCRL SKIGATRRPP PARVRVAVRL RPFVDGTAGA SDPPCVRGMD SCSLEIANWR NHQETLKYQF DAFYGERSTQ QDIYAGSVQP ILRHLLEGQN ASVLAYGPTG AGKTHTMLGS PEQPGVIPRA LMDLLQLTRE EGAEGRPWAL SVTMSYLEIY QEKVLDLLDP ASGDLVIRED CRGNILIPGL SQKPISSFAD FERHFLPASR NRTVGATRLN QRSSRSHAVL LVKVDQRERL APFRQREGKL YLIDLAGSED NRRTGNKGLR LKESGAINTS LFVLGKVVDA LNQGLPRVPY RDSKLTRLLQ DSLGGSAHSI LIANIAPERR FYLDTVSALN FAARSKEVIN RPFTNESLQP HALGPVKLSQ KELLGPPEAK RARGPEEEEI GSPEPMAAPA SASQKLSPLQ KLSSMDPAML ERLLSLDRLL ASQGSQGAPL LSTPKRERMV LMKTVEEKDL EIERLKTKQK ELEAKMLAQK AEEKENHCPT MLRPLSHRTV TGAKPLKKAV VMPLQLIQEQ AASPNAEIHI LKNKGRKRKL ESLDALEPEE KAEDCWELQI SPELLAHGRQ KILDLLNEGS ARDLRSLQRI GPKKAQLIVG WRELHGPFSQ VEDLERVEGI TGKQMESFLK ANILGLAAGQ RCGAS. It is sometimes possible for the material contained within the vial of "KIF22, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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