Rabbit HNRNPL Polyclonal Antibody | anti-HNRNPL antibody

HNRNPL Rabbit Polyclonal

Cat. Num. AAA7600189

• Gene Names: HNRNPL; HNRPL; hnRNP-L; P/OKcl.14
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunofluorescence, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: HNRNPL; Polyclonal Antibody; HNRNPL Rabbit Polyclonal; anti-HNRNPL antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 589

• Applicable Applications for anti-HNRNPL antibody: ELISA (EIA), Western Blot (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)
• Immunogen: Heterogeneous nuclear ribonucleoprotein L
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded rat kidney using MBS7600189 (HNRNPL Antibody) at dilution of 1:50)

Western Blot (WB)

(RAW 264.7 cells were subjected to SDS PAGE followed by western blot with MBS7600189 (HNRNPL Antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 52632383
• NCBI GeneID: 3191
• NCBI Accession #: NP_001524.2
• NCBI GenBank Nucleotide #: NM_001533.2
• Molecular Weight: 50,561 Da
• NCBI Official Full Name: heterogeneous nuclear ribonucleoprotein L isoform a
• NCBI Official Synonym Full Names: heterogeneous nuclear ribonucleoprotein L
• NCBI Official Symbol: HNRNPL
• NCBI Official Synonym Symbols: HNRPL; hnRNP-L; P/OKcl.14
• NCBI Protein Information: heterogeneous nuclear ribonucleoprotein L
• UniProt Protein Name: Heterogeneous nuclear ribonucleoprotein L
• Protein Family: Heterogeneous nuclear ribonucleoprotein
• UniProt Gene Name: HNRNPL
• UniProt Synonym Gene Names: HNRPL; hnRNP L
• UniProt Entry Name: HNRPL_HUMAN

NCBI Description

Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

hnRNP L: This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Is associated with most nascent transcripts including those of the landmark giant loops of amphibian lampbrush chromosomes. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA splicing; RNA-binding

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: cytoplasm; membrane; nucleoplasm; nucleus; pronucleus; ribonucleoprotein complex

Molecular Function: nucleotide binding; protein binding; RNA binding

Biological Process: gene expression; nuclear mRNA splicing, via spliceosome; regulation of alternative nuclear mRNA splicing, via spliceosome; RNA processing