Rabbit anti-Human KIF22 Polyclonal Antibody | anti-KIF22 antibody

KIF22 Polyclonal Antibody

Cat. Num. AAA2522676

• Gene Names: KIF22; KID; OBP; KNSL4; OBP-1; OBP-2; SEMDJL2; A-328A3.2
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity purification
• Synonyms: KIF22; Polyclonal Antibody; KIF22 Polyclonal Antibody; KID; OBP; KNSL4; OBP-1; OBP-2; SEMDJL2; A-328A3.2; anti-KIF22 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purification
• Sequence Length: 597

• Applicable Applications for anti-KIF22 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:200-1:1000; IHC: 1:50-1:200
• Immunogen: Synthetic peptide of human KIF22
• Calculated MW: 73kDa
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20°C. Avoid freeze / thaw cycles.

Western Blot (WB)

(Western Blot analysis of A431, MCF-7 and Hela cell using KIF22 Polyclonal Antibody at dilution of 1:200)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human colon cancer using KIF22 Polyclonal Antibody at dilution of 1:30)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human liver cancer using KIF22 Polyclonal Antibody at dilution of 1:30)

Related Product Information for anti-KIF22 antibody

The protein encoded by this gene is a member of the kinesin-like protein family. The family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. The C-terminal half of this protein has been shown to bind DNA. Studies with the Xenopus homolog suggests its essential role in metaphase chromosome alignment and maintenance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 372266148
• NCBI GeneID: 3835
• NCBI Accession #: NP_001243199.1
• NCBI GenBank Nucleotide #: NM_001256270.1
• NCBI Official Full Name: kinesin-like protein KIF22 isoform 2
• NCBI Official Synonym Full Names: kinesin family member 22
• NCBI Official Symbol: KIF22
• NCBI Official Synonym Symbols: KID; OBP; KNSL4; OBP-1; OBP-2; SEMDJL2; A-328A3.2
• NCBI Protein Information: kinesin-like protein KIF22; kinesin-like DNA-binding protein pseudogene; kinesin-like protein 4; oriP binding protein; origin of plasmid DNA replication-binding protein
• UniProt Protein Name: Kinesin-like protein KIF22
• Protein Family: Kinesin-like protein
• UniProt Gene Name: KIF22
• UniProt Synonym Gene Names: KID; KNSL4
• UniProt Entry Name: KIF22_HUMAN

NCBI Description

The protein encoded by this gene is a member of the kinesin-like protein family. The family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. The C-terminal half of this protein has been shown to bind DNA. Studies with the Xenopus homolog suggests its essential role in metaphase chromosome alignment and maintenance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Uniprot Description

KIF22: Kinesin family that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA. Defects in KIF22 are the cause of spondyloepimetaphyseal dysplasia with joint laxity, type 2 (SEMDJL2). A bone disease characterized by short stature, distinctive midface retrusion, progressive knee malalignment (genu valgum and/or varum), generalized ligamentous laxity, and mild spinal deformity. Intellectual development is not impaired. Radiographic characteristics include significantly retarded epiphyseal ossification that evolves into epiphyseal dysplasia and precocious osteoarthritis, metaphyseal irregularities and vertical striations, constricted femoral neck, slender metacarpals and metatarsals, and mild thoracolumbar kyphosis or scoliosis with normal or mild platyspondyly. The most distinctive features for differential diagnosis of SEMDJL2 are the slender metacarpals and phalanges and the progressive degeneration of carpal bones; however, these 2 features are evident only in older children and young adults. The soft consistency of cartilage in the airways leads to laryngotracheomalacia with proneness to respiratory obstruction and inspiratory stridor in infancy and childhood. Belongs to the kinesin-like protein family.

Protein type: Motor; Microtubule-binding

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: nucleoplasm; kinetochore; microtubule; kinesin complex; focal adhesion; cytoplasm; spindle; nucleus; cytosol; chromatin

Molecular Function: DNA binding; microtubule binding; ATPase activity; microtubule motor activity; ATP binding

Biological Process: mitosis; sister chromatid cohesion; antigen processing and presentation of exogenous peptide antigen via MHC class II; DNA repair; blood coagulation; mitotic metaphase plate congression; microtubule-based movement

Disease: Spondyloepimetaphyseal Dysplasia With Joint Laxity Type 2