Immunohistochemistry (IHC)
(Immunochemical staining of human KRT76 in human skin with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections.)
Rabbit anti-Human keratin 76/KRT76 Polyclonal Antibody | anti-KRT76 antibody
Anti-keratin 76/KRT76 Antibody, Rabbit Polyclonal
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
keratin 76/KRT76; Polyclonal Antibody; Anti-keratin 76/KRT76 Antibody; Rabbit Polyclonal; keratin 76/KRT76 Antibody; Rabbit PAb; Antigen Affinity Purified; Anti-HUMCYT2A Antibody; Anti-KRT2P Antibody; anti-KRT76 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human keratin 76/KRT76
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; PBS, pH7.0 with 0.03% Proclin300
Applicable Applications for anti-KRT76 antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:200-1:1000
Immunogen
E Coli-derived Human keratin 76/KRT76 fragment
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with E Coli-derived Human keratin 76/KRT76 fragment, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of human KRT76 in human skin with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human KRT76 in human skin with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human KRT76 in human tonsil with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human KRT76 in human tonsil with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections.)
Related Product Information for anti-KRT76 antibody
Keratin 76 (Krt76) is expressed in the differentiated epithelial layers of skin, oral cavity and squamous stomach. Krt76 downregulation in human oral squamous cell carcinomas (OSCC) correlates with poor prognosis. Krt76 is a type II intermediate filament protein expressed in the differentiating, non-proliferative layers of a subset of stratified epithelia in human and mouse. Krt76 is the most significantly downregulated gene encoding a structural protein in human oral squamous cell carcinoma (OSCC) and correlates strongly with poor prognosis. OSCC arises from the multilayered epithelial lining of the mouth and the lips. It involves mostly the tongue, but can also occur in the floor of the mouth, gingiva, lip, cheek and palate. In patients, KRT76 is detected in 100% of normal gingivobuccal epithelial biopsies, 44% of oral preneoplastic lesions and 35% of OSCC.
References
Sequeira I, et al. (2019) The role of keratins in modulating carcinogenesis via communication with cells of the immune system. Cell Stress 3 (4): 136-138.Sequeira I, et al. (2018) Immunomodulatory role of keratin 76 in oral and gastric cancer. Nat Commun 9 (1): 3437.Ambatipudi S, et al. (2013) Downregulation of keratin 76 expression during oral carcinogenesis of human, hamster and mouse. PLoS One 8 (7): e70688.
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Product Notes
The KRT76 (Catalog #AAA8108773) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-keratin 76/KRT76 Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's keratin 76/KRT76 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:200-1:1000. Researchers should empirically determine the suitability of the KRT76 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "keratin 76/KRT76, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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