Rabbit anti-Human, Mouse KCNV1 Polyclonal Antibody | anti-KCNV1 antibody

KCNV1, NT (KCNV1, Potassium voltage-gated channel subfamily V member 1, Neuronal potassium channel alpha subunit HNKA, Voltage-gated potassium channel subunit Kv8.1) (PE)

Cat. Num. AAA6312785

• Gene Names: KCNV1; HNKA; KCNB3; KV2.3; KV8.1
• Reactivity: Human, Mouse
• Applications: Flow Cytometry, Functional Assay, Immunohistochemistry, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: KCNV1; Polyclonal Antibody; NT (KCNV1; Potassium voltage-gated channel subfamily V member 1; Neuronal potassium channel alpha subunit HNKA; Voltage-gated potassium channel subunit Kv8.1) (PE); Voltage-gated potassium channel subunit Kv8.1; anti-KCNV1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-KCNV1 antibody: Flow Cytometry (FC/FACS), FLISA, Immunohistochemistry (IHC), Western Blot (WB)
• Application Notes: FC/FACS: 1:10-50; FLISA: 1:1,000; IHC: 1:50-100; WB: 1:100-500; Applications are based on unconjugated antibody.
• Immunogen: KCNV1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 144-174 amino acids from the N-terminal region of human KCNV1.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(KCNV1 Antibody (N-term) western blot analysis in mouse heart tissue lysates (15ug/lane).This demonstrates the KCNV1 antibody detected KCNV1 protein (arrow).)

Immunohistochemistry (IHC)

(KCNV1 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded mouse kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the KCNV1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)

Flow Cytometry (FC/FACS)

(KCNV1 Antibody (N-term) flow cytometric analysis of CEM cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)

Related Product Information for anti-KCNV1 antibody

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium voltage-gated channel subfamily V. This protein is essentially present in the brain, and its role might be to inhibit the function of a particular class of outward rectifier potassium channel types.

Product Categories/Family for anti-KCNV1 antibody

Antibodies; Ion Channel

References

Gutman, G.A., et al. Pharmacol. Rev. 57(4):473-508(2005). Ebihara, M., et al. Gene 325, 89-96 (2004): Sano, A., et al. Epilepsia 43 SUPPL 9, 26-31 (2002): Salinas, M., et al. J. Biol. Chem. 272(13):8774-8780(1997). Hugnot, J.P., et al. EMBO J. 15(13):3322-3331(1996).

NCBI and Uniprot Product Information

• NCBI GI #: 7657289
• NCBI GeneID: 27012
• NCBI Accession #: NP_055194.1
• NCBI GenBank Nucleotide #: NM_014379.3
• UniProt Accession #: Q6PIU1; Q9UHJ4
• Molecular Weight: 56,304 Da
• NCBI Official Full Name: potassium voltage-gated channel subfamily V member 1
• NCBI Official Synonym Full Names: potassium voltage-gated channel modifier subfamily V member 1
• NCBI Official Symbol: KCNV1
• NCBI Official Synonym Symbols: HNKA; KCNB3; KV2.3; KV8.1
• NCBI Protein Information: potassium voltage-gated channel subfamily V member 1
• UniProt Protein Name: Potassium voltage-gated channel subfamily V member 1
• Protein Family: Potassium voltage-gated channel subfamily
• UniProt Gene Name: KCNV1

NCBI Description

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium voltage-gated channel subfamily V. This protein is essentially present in the brain, and its role might be to inhibit the function of a particular class of outward rectifier potassium channel types. [provided by RefSeq, Jul 2008]

Uniprot Description

KCNV1: Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes. Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 8q23.2

Cellular Component: integral component of plasma membrane; plasma membrane; voltage-gated potassium channel complex

Molecular Function: ion channel inhibitor activity; potassium channel regulator activity; voltage-gated potassium channel activity

Biological Process: potassium ion transport; protein homooligomerization; regulation of molecular function