Structure
PG-S3-001, Inhibitor
PG-S3-001
Purity
>98% (HPLC)
Synonyms
PG-S3-001; inhibitor
Purity/Purification
>98% (HPLC)
Target
STAT
Receptor
STAT
Chemical Name
4-{(4-Cyclohexyl-benzyl)-[3-methyl-2-(methyl-pentafluorobenzenesulfonyl-amino)-butyryl]-amino}-benzoic acid
Molecular Formula
C32H33F5N2O5S
CAS Number
2047372-50-7
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for PG-S3-001, inhibitor
PG-S3-001 is a small molecule STAT3 inhibitor that binds to STAT3 protein potently with Kd of 324nM by surface plasmon resonance; shows no effect in a kinome screen (>100 cancer-relevant kinases); inhibits phosphorylation of STAT3 at Y705, inhibits patient-derived pancreatic cancer cell proliferation in vitro and in vivo in the low micromolar range; exhibits in vivo efficacy on pancreatic cancer xenografts.
Product Categories/Family for PG-S3-001, inhibitor
References
1. Arpin CC, et al. Mol Cancer Ther. 2016 May; 15 (5):794-805.
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Product Notes
The PG-S3-001 (Catalog #AAA3603182) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "PG-S3-001, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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