Rabbit anti-Human, Mouse KCNV1 Polyclonal Antibody | anti-KCNV1 antibody

KCNV1, NT (KCNV1, Potassium voltage-gated channel subfamily V member 1, Neuronal potassium channel alpha subunit HNKA, Voltage-gated potassium channel subunit Kv8.1)

Cat. Num. AAA6000155

• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot, Immunohistochemistry, Flow Cytometry, Functional Assay
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: KCNV1; Polyclonal Antibody; NT (KCNV1; Potassium voltage-gated channel subfamily V member 1; Neuronal potassium channel alpha subunit HNKA; Voltage-gated potassium channel subunit Kv8.1); Anti -KCNV1; anti-KCNV1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human, mouse
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-KCNV1 antibody: ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
• Application Notes: Suitable for use in Western Blot, Immunohistochemistry, Flow Cytometry, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500; Immunohistochemistry: 1:50-100; Flow Cytometry: 1:10-50
• Immunogen: KCNV1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 144-174 amino acids from the N-terminal region of human KCNV1.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(KCNV1 Antibody (N-term) western blot analysis in mouse heart tissue lysates (15ug/lane).This demonstrates the KCNV1 antibody detected KCNV1 protein (arrow).)

Immunohistochemistry (IHC)

(KCNV1 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded mouse kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the KCNV1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)

Flow Cytometry (FC/FACS)

(KCNV1 Antibody (N-term) flow cytometric analysis of CEM cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)

Related Product Information for anti-KCNV1 antibody

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium voltage-gated channel subfamily V. This protein is essentially present in the brain, and its role might be to inhibit the function of a particular class of outward rectifier potassium channel types.

Product Categories/Family for anti-KCNV1 antibody

Antibodies; Abs to Ion Channel

NCBI and Uniprot Product Information

• NCBI GI #: 112362247
• NCBI GeneID: 505732
• UniProt Accession #: Q0P583
• Molecular Weight: 56,725 Da
• NCBI Official Full Name: KCNV1 protein
• NCBI Official Synonym Full Names: potassium channel, subfamily V, member 1<
• NCBI Official Symbol: KCNV1
• NCBI Protein Information: potassium voltage-gated channel subfamily V member 1; voltage-gated potassium channel subunit Kv8.1
• UniProt Protein Name: Potassium voltage-gated channel subfamily V member 1
• Protein Family: Potassium voltage-gated channel subfamily
• UniProt Gene Name: KCNV1
• UniProt Entry Name: KCNV1_BOVIN

Uniprot Description

Function: Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes

By similarity.

Subunit structure: Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1

By similarity.

Subcellular location: Cell membrane; Multi-pass membrane protein

By similarity. Note: Has to be associated with another potassium channel subunit to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB2

By similarity.

Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position

By similarity.

Sequence similarities: Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily. [View classification]