Goat anti-Human ABHD4 Polyclonal Antibody | anti-ABHD4 antibody

ABHD4, ID (Abhydrolase Domain-containing Protein 4, Alpha/beta-hydrolase 4, Lyso-N-acylphosphatidylethanolamine Lipase)

Cat. Num. AAA6004362

• Gene Names: ABHD4; ABH4
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: ABHD4; Polyclonal Antibody; ID (Abhydrolase Domain-containing Protein 4; Alpha/beta-hydrolase 4; Lyso-N-acylphosphatidylethanolamine Lipase); Anti -ABHD4; anti-ABHD4 antibody

• Host: Goat
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human ABHD4. Species sequence homology: Canine and mouse.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in TBS, pH 7.3, 0.5% BSA, 0.02% sodium azide.

• Applicable Applications for anti-ABHD4 antibody: ELISA (EL/EIA), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA and Immunohistochemistry.; Dilution: ELISA: 1:4000; Immunohistochemistry (Formalin-fixed, paraffin-embedded): 3.75ug/ml
• Immunogen: Synthetic peptide corresponding to C-RPTNPSEIRAP from an internal region of human ABHD4.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(Human Kidney (formalin-fixed, paraffin-embedded) stained with ABHD4 antibody at 3.75ug/ml followed by biotinylated goat IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.)

Related Product Information for anti-ABHD4 antibody

The protein encoded by this gene belongs to a large family of proteins defined by an alpha/beta hydrolase fold, and contains three sequence motifs that correspond to a catalytic triad found in the esterase/lipase/thioesterase subfamily. It differs from other members of this subfamily in that its putative catalytic triad contains an asparagine instead of the serine residue. Mutations in this gene have been associated with Chanarin-Dorfman syndrome, a triglyceride storage disease with impaired long-chain fatty acid oxidation.

Product Categories/Family for anti-ABHD4 antibody

Antibodies; Abs to Enzymes; Lipase

NCBI and Uniprot Product Information

• NCBI GI #: 50658087
• NCBI GeneID: 63874
• NCBI Accession #: NP_071343.2
• NCBI GenBank Nucleotide #: NM_022060.2
• UniProt Accession #: Q8TB40; Q9H9E0
• Molecular Weight: 38,794 Da
• NCBI Official Full Name: abhydrolase domain-containing protein 4
• NCBI Official Synonym Full Names: abhydrolase domain containing 4
• NCBI Official Symbol: ABHD4
• NCBI Official Synonym Symbols: ABH4
• NCBI Protein Information: abhydrolase domain-containing protein 4; alpha/beta-hydrolase 4; lyso-N-acylphosphatidylethanolamine lipase
• UniProt Protein Name: Abhydrolase domain-containing protein 4
• Protein Family: Protein
• UniProt Gene Name: ABHD4
• UniProt Entry Name: ABHD4_HUMAN

Uniprot Description

ABHD4: Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine. Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.

Protein type: Hydrolase; EC 3.1.1.-

Chromosomal Location of Human Ortholog: 14q11.2

Molecular Function: hydrolase activity

Biological Process: lipid catabolic process