Rabbit anti-Human KCNQ1 Polyclonal Antibody | anti-KCNQ1 antibody

KCNQ1, NT (KCNQ1, KCNA8, KCNA9, KVLQT1, Potassium voltage-gated channel subfamily KQT member 1, IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1, KQT-like 1, Voltage-gated potassium channel subunit Kv7.1) (Azide free) (HRP)

Cat. Num. AAA6312702

• Gene Names: KCNQ1; LQT; RWS; WRS; LQT1; SQT2; ATFB1; ATFB3; JLNS1; KCNA8; KCNA9; Kv1.9; Kv7.1; KVLQT1
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: KCNQ1; Polyclonal Antibody; NT (KCNQ1; KCNA8; KCNA9; KVLQT1; Potassium voltage-gated channel subfamily KQT member 1; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; KQT-like 1; Voltage-gated potassium channel subunit Kv7.1) (Azide free) (HRP); Voltage-gated potassium channel subunit Kv7.1; anti-KCNQ1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).

• Applicable Applications for anti-KCNQ1 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: KCNQ1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-42 amino acids from the N-terminal region of human KCNQ1.
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(KCNQ1 Antibody (N-term) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the KCNQ1 antibody detected the KCNQ1 protein (arrow).)

Related Product Information for anti-KCNQ1 antibody

This gene encodes a voltage-gated potassium channel required for the repolarization phase of the cardiac action potential. The gene product can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome and familial atrial fibrillation. The gene is located in a region of chromosome 11 that contains a number of contiguous genes, which are abnormally imprinted in cancer and the Beckwith-Wiedemann syndrome. This gene is also imprinted, with preferential expression from the maternal allele in some tissues, excluding cardiac muscle. Alternatively spliced transcripts encoding distinct isoforms have been described.

Product Categories/Family for anti-KCNQ1 antibody

Antibodies; Ion Channel

References

Nakajo, K., et al. Proc. Natl. Acad. Sci. U.S.A. 107(44):18862-18867(2010). Ren, X.Q., et al. Am. J. Physiol. Heart Circ. Physiol. 299 (5), H1525-H1534 (2010): Tester, D.J., et al. Am. J. Cardiol. 106(8):1124-1128(2010). Stuebe, A.M., et al. Am. J. Obstet. Gynecol. 203 (3), 283 (2010): Mohammad, F., et al. Epigenetics 4(5):277-286(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 32479527
• NCBI GeneID: 3784
• NCBI Accession #: NP_000209.2; NP_861463.1
• NCBI GenBank Nucleotide #: NM_000218.2
• UniProt Accession #: P51787; O00347; O60607; O94787; Q7Z6G9; Q92960; Q9UMN8; Q9UMN9
• Molecular Weight: 676 (549)
• NCBI Official Full Name: potassium voltage-gated channel subfamily KQT member 1
• NCBI Official Synonym Full Names: potassium voltage-gated channel, KQT-like subfamily, member 1
• NCBI Official Symbol: KCNQ1
• NCBI Official Synonym Symbols: LQT; RWS; WRS; LQT1; SQT2; ATFB1; ATFB3; JLNS1; KCNA8; KCNA9; Kv1.9; Kv7.1; KVLQT1
• NCBI Protein Information: potassium voltage-gated channel subfamily KQT member 1; slow delayed rectifier channel subunit; voltage-gated potassium channel subunit Kv7.1; kidney and cardiac voltage dependend K+ channel; IKs producing slow voltage-gated potassium channel subunit alph
• UniProt Protein Name: Potassium voltage-gated channel subfamily KQT member 1
• Protein Family: KCNQ1 downstream neighbor protein
• UniProt Gene Name: KCNQ1
• UniProt Synonym Gene Names: KCNA8; KCNA9; KVLQT1
• UniProt Entry Name: KCNQ1_HUMAN