Goat anti-Human Kv7.1 Polyclonal Antibody | anti-KCNQ1 antibody

Kv7.1 (KCNQ1, Potassium Voltage-gated Channel, KQT-like Subfamily, Member 1, IKs Producing Slow Voltage-gated Potassium Channel Subunit alpha KvLQT1, KQT-like 1, Voltage-gated Potassium Channel Subunit Kv7.1, Kidney and Cardiac Voltage Dependend K+ Channe

Cat. Num. AAA621168

• Gene Names: KCNQ1; LQT; RWS; WRS; LQT1; SQT2; ATFB1; ATFB3; JLNS1; KCNA8; KCNA9; Kv1.9; Kv7.1; KVLQT1
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Kv7.1; Polyclonal Antibody; Kv7.1 (KCNQ1; Potassium Voltage-gated Channel; KQT-like Subfamily; Member 1; IKs Producing Slow Voltage-gated Potassium Channel Subunit alpha KvLQT1; KQT-like 1; Voltage-gated Potassium Channel Subunit Kv7.1; Kidney and Cardiac Voltage Dependend K+ Channe; Anti -Kv7.1 (KCNQ1; anti-KCNQ1 antibody

• Host: Goat
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human Kv7.1 at ~60kD. Species sequence homology: bovine, mouse, rat and canine
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in Tris, pH 7.3, 0.5% BSA, 0.02% sodium azide, before the addition of glyceorl to 40%.

• Applicable Applications for anti-KCNQ1 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: ELISA:1:8000; Western Blot:1-3ug/ml
• Immunogen: Synthetic peptide corresponding to C-EQLTVPRRGPDEGS, from the C-Terminus of human KCNQ1.
• Positive Control: Human Heart lysates
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Western Blot (WB)

(Western Blot of Human Heart lysate (35ug protein in RIPA buffer) using MBS621168 at 1ug/ml. ECL detection.)

Related Product Information for anti-KCNQ1 antibody

This gene encodes a protein for a voltage-gated potassium channel required for the repolarization phase of the cardiac action potential. The gene product can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome, Romano-Ward syndrome, Jervell and Lange-Nielsen syndrome and familial atrial fibrillation. The gene is located in a region of chromosome 11 that contains a large number of contiguous genes that are abnormally imprinted in cancer and the Beckwith-Wiedemann syndrome. Two alternative transcripts encoding distinct isoforms have been described.

Product Categories/Family for anti-KCNQ1 antibody

Antibodies; Abs to Ion Channel

NCBI and Uniprot Product Information

• NCBI GI #: 108752068
• NCBI GeneID: 3784
• UniProt Accession #: P51787; O00347; O60607; O94787; Q7Z6G9; Q92960; Q9UMN8; Q9UMN9
• Molecular Weight: 74,699 Da
• NCBI Official Full Name: KCNQ1 protein
• NCBI Official Synonym Full Names: potassium voltage-gated channel, KQT-like subfamily, member 1
• NCBI Official Symbol: KCNQ1
• NCBI Official Synonym Symbols: LQT; RWS; WRS; LQT1; SQT2; ATFB1; ATFB3; JLNS1; KCNA8; KCNA9; Kv1.9; Kv7.1; KVLQT1
• NCBI Protein Information: potassium voltage-gated channel subfamily KQT member 1; slow delayed rectifier channel subunit; voltage-gated potassium channel subunit Kv7.1; kidney and cardiac voltage dependend K+ channel; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1
• UniProt Protein Name: Potassium voltage-gated channel subfamily KQT member 1
• Protein Family: Potassium voltage-gated channel subfamily
• UniProt Gene Name: KCNQ1
• UniProt Synonym Gene Names: KCNA8; KCNA9; KVLQT1
• UniProt Entry Name: KCNQ1_HUMAN

NCBI Description

This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. This gene exhibits tissue-specific imprinting, with preferential expression from the maternal allele in some tissues, and biallelic expression in others. This gene is located in a region of chromosome 11 amongst other imprinted genes that are associated with Beckwith-Wiedemann syndrome (BWS), and itself has been shown to be disrupted by chromosomal rearrangements in patients with BWS. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]

Uniprot Description

Kv7.1: a voltage-gated potassium channel protein required for the repolarization phase of the cardiac action potential. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in cystic fibrosis and pathologically stimulated in cholera and other forms of secretory diarrhea. Abundantly expressed in heart, pancreas, prostate, kidney, small intestine and peripheral blood leukocytes. Less abundant in placenta, lung, spleen, colon, thymus, testis and ovaries. Three alternatively spliced isoforms have been described.

Protein type: Membrane protein, multi-pass; Channel, potassium; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: voltage-gated potassium channel complex; cytoplasmic vesicle membrane; lysosome; basolateral plasma membrane; early endosome; late endosome; plasma membrane

Molecular Function: calmodulin binding; protein binding; voltage-gated potassium channel activity; delayed rectifier potassium channel activity; protein phosphatase 1 binding

Biological Process: synaptic transmission; genetic imprinting; sensory perception of sound; positive regulation of heart rate; gene silencing; regulation of heart contraction; cardiac muscle contraction

Disease: Jervell And Lange-nielsen Syndrome 1; Beckwith-wiedemann Syndrome; Atrial Fibrillation, Familial, 3; Short Qt Syndrome 2; Long Qt Syndrome 1