Rabbit anti-Human KCNE1L Polyclonal Antibody | anti-KCNE1L antibody

KCNE1L Polyclonal Antibody

Cat. Num. AAA3006829

• Gene Names: KCNE5; KCNE1L
• Reactivity: Human
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: KCNE1L; Polyclonal Antibody; KCNE1L Polyclonal Antibody; Potassium voltage-gated channel subfamily E; member 1-like protein; AMME syndrome candidate gene 2 protein; AMMECR2; Organismi Homo sapiens (Human); anti-KCNE1L antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: KCNE1L polyclonal antibody detects endogenous levels of KCNE1L protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 142

• Applicable Applications for anti-KCNE1L antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthetic peptide corresponding to residues in Human KCNE1L.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of KCNE1L polyclonal antibody at 1:500 dilutionLane1:Hela whole cell lysateLane2:MCF-7 whole cell lysate)

Related Product Information for anti-KCNE1L antibody

KCNE genes encode small, single transmembrane domain peptides that associate with pore-forming å-subunits to form K+ channels with unique characteristics. Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. KCNE1L (KCNE1-like), also known as KCNE5, potassium voltage-gated channel subfamily E member 1-like protein or AMMECR2, is a 142 amino acid single-pass type I membrane protein belonging to the potassium channel KCNE family. Defects of the KCNE1L gene have been linked to the cardiac and some neurological abnormalities observed in patients with AMME (Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis) contiguous gene syndrome. KCNE1L is primarily expressed in skeletal muscle, brain, placenta, spinal cord and heart.

NCBI and Uniprot Product Information

• NCBI GI #: 6912442
• NCBI GeneID: 23630
• NCBI Accession #: NP_036414.1
• NCBI GenBank Nucleotide #: NP_036414.1
• UniProt Accession #: Q9UJ90
• Molecular Weight: ~ 15kDa
• NCBI Official Full Name: potassium voltage-gated channel subfamily E regulatory beta subunit 5
• NCBI Official Synonym Full Names: potassium voltage-gated channel subfamily E regulatory subunit 5
• NCBI Official Symbol: KCNE5
• NCBI Official Synonym Symbols: KCNE1L
• NCBI Protein Information: potassium voltage-gated channel subfamily E regulatory beta subunit 5
• UniProt Protein Name: Potassium voltage-gated channel subfamily E regulatory beta subunit 5
• UniProt Gene Name: KCNE5

NCBI Description

This gene encodes a member of a family of single pass transmembrane domain proteins that function as ancillary subunits to voltage-gated potassium channels. Members of this family affect diverse processes in potassium channel regulation, including ion selectivity, voltage dependence, and anterograde recycling from the plasma membrane. Variants of this gene are associated with idiopathic ventricular fibrillation and Brugada syndrome. [provided by RefSeq, Nov 2016]

Uniprot Description

KCNE1L: Defects in KCNE1L are involved in Alport syndrome with mental retardation midface hypoplasia and elliptocytosis (ATS-MR). A X-linked contiguous gene deletion syndrome characterized by glomerulonephritis, deafness, mental retardation, midface hypoplasia and elliptocytosis. Belongs to the potassium channel KCNE family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq23

Cellular Component: plasma membrane; voltage-gated potassium channel complex

Molecular Function: potassium channel regulator activity; protein binding; voltage-gated potassium channel activity

Biological Process: cardiac muscle contraction; regulation of heart contraction