Rabbit anti-Human KCE1L Polyclonal Antibody | anti-KCE1L antibody

KCE1L, ID (KCNE1L, AMMECR2, Potassium voltage-gated channel subfamily E member 1-like protein, AMME syndrome candidate gene 2 protein) (Azide free) (HRP)

Cat. Num. AAA6312185

• Gene Names: KCNE5; KCNE1L
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: KCE1L; Polyclonal Antibody; ID (KCNE1L; AMMECR2; Potassium voltage-gated channel subfamily E member 1-like protein; AMME syndrome candidate gene 2 protein) (Azide free) (HRP); KCNE1L; AMME syndrome candidate gene 2 protein; anti-KCE1L antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).

• Applicable Applications for anti-KCE1L antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: KCE1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 74~104 amino acids from the Central region of human KCE1L.
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis of KCE1L Antibody (Center) in NCI-H460 cell line lysates (35ug/lane). KCE1L (arrow) was detected using the purified Pab.)

Related Product Information for anti-KCE1L antibody

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a membrane protein which has sequence similarity to the KCNE1 gene product, a member of the potassium channel, voltage-gated, isk-related subfamily. This intronless gene is deleted in AMME contiguous gene syndrome and may be involved in the cardiac and neurologic abnormalities found in the AMME contiguous gene syndrome.

Product Categories/Family for anti-KCE1L antibody

Antibodies; Ion Channel

References

Ravn, L.S., et al. Heart Rhythm 5(3):427-435(2008). Lundquist, A.L., et al. Genomics 87(1):119-128(2006). Ravn, L.S., et al. Am. J. Cardiol. 96(3):405-407(2005). Yang, Y., et al. Am. J. Hum. Genet. 75(5):899-905(2004). Hofman-Bang, J., et al. Clin. Chim. Acta 345 (1-2), 49-53 (2004). Piccini, M., et al. Genomics 60(3):251-257(1999).

NCBI and Uniprot Product Information

• NCBI GI #: 6912442
• NCBI GeneID: 23630
• NCBI Accession #: NP_036414.1
• NCBI GenBank Nucleotide #: NM_012282.3
• UniProt Accession #: Q9UJ90; Q5JWV7
• Molecular Weight: 14,993 Da
• NCBI Official Full Name: potassium voltage-gated channel subfamily E regulatory beta subunit 5
• NCBI Official Synonym Full Names: potassium voltage-gated channel subfamily E regulatory subunit 5
• NCBI Official Symbol: KCNE5
• NCBI Official Synonym Symbols: KCNE1L
• NCBI Protein Information: potassium voltage-gated channel subfamily E regulatory beta subunit 5
• UniProt Protein Name: Potassium voltage-gated channel subfamily E regulatory beta subunit 5
• UniProt Gene Name: KCNE5

NCBI Description

This gene encodes a member of a family of single pass transmembrane domain proteins that function as ancillary subunits to voltage-gated potassium channels. Members of this family affect diverse processes in potassium channel regulation, including ion selectivity, voltage dependence, and anterograde recycling from the plasma membrane. Variants of this gene are associated with idiopathic ventricular fibrillation and Brugada syndrome. [provided by RefSeq, Nov 2016]

Uniprot Description

KCNE1L: Defects in KCNE1L are involved in Alport syndrome with mental retardation midface hypoplasia and elliptocytosis (ATS-MR). A X-linked contiguous gene deletion syndrome characterized by glomerulonephritis, deafness, mental retardation, midface hypoplasia and elliptocytosis. Belongs to the potassium channel KCNE family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq23

Cellular Component: plasma membrane; voltage-gated potassium channel complex

Molecular Function: potassium channel regulator activity; protein binding; voltage-gated potassium channel activity

Biological Process: cardiac muscle contraction; regulation of heart contraction