Western Blot (WB)
(Host: RatTarget Name: KCND3Sample Tissue: Rat LiverAntibody Dilution: 1ug/ml)
Rabbit KCND3 Polyclonal Antibody | anti-KCND3 antibody
KCND3 antibody - middle region
Western Blot (WB)
(Host: RatTarget Name: KCND3Sample Tissue: Rat LiverAntibody Dilution: 1ug/ml)
Western Blot (WB)
(Host: RatTarget Name: KCND3Sample Tissue: Rat LiverAntibody Dilution: 1ug/ml)
Western Blot (WB)
(WB Suggested Anti-KCND3 Antibody Titration: 1.25ug/mlELISA Titer: 1:12500Positive Control: HepG2 cell lysate)
Western Blot (WB)
(WB Suggested Anti-KCND3 Antibody Titration: 1.25ug/mlELISA Titer: 1:12500Positive Control: HepG2 cell lysate)
Target Description: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). KCND3 encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential.
NCBI and Uniprot Product Information
NCBI Description
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
Kv4.3: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. KCND3 rare variants may confer risk for lethal ventricular arrhytmias and be associated with autopsy-negative sudden unexplained death syndrome (SUDS). Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.3/KCND3 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Channel, potassium; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p13.3
Cellular Component: voltage-gated potassium channel complex; cell soma; dendrite; plasma membrane; sarcolemma
Molecular Function: protein binding; metal ion binding; delayed rectifier potassium channel activity; A-type (transient outward) potassium channel activity
Biological Process: synaptic transmission; protein homooligomerization; potassium ion transport
Disease: Brugada Syndrome 9; Spinocerebellar Ataxia 19
Research Articles on KCND3
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Product Notes
The KCND3 kcnd3 (Catalog #AAA3202456) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The KCND3 antibody - middle region reacts with Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's KCND3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the KCND3 kcnd3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: KARLARIRVA KTGSSNAYLH SKRNGLLNEA LELTGTPEEE HMGKTTSLIE. It is sometimes possible for the material contained within the vial of "KCND3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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