Rabbit KCND3 Polyclonal Antibody | anti-KCND3 antibody

KCND3 Polyclonal Antibody

Cat. Num. AAA3011843

• Gene Names: KCND3; KV4.3; SCA19; SCA22; BRGDA9; KCND3L; KCND3S; KSHIVB
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: KCND3; Polyclonal Antibody; KCND3 Polyclonal Antibody; Potassium voltage-gated channel subfamily D member 3; Voltage-gated potassium channel subunit Kv4.3; anti-KCND3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: KCND3 polyclonal antibody detects endogenous levels of KCND3 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 655

• Applicable Applications for anti-KCND3 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:500-1:2000; IHC: 1:50-1:200
• Immunogen: Recombinant full length Human KCND3.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot analysis of extracts of various cell lines, using KCND3 antibody.)

Related Product Information for anti-KCND3 antibody

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 27436984
• NCBI GeneID: 3752
• NCBI Accession #: NP_004971.2
• NCBI GenBank Nucleotide #: NP_004971.2
• UniProt Accession #: Q9UK17
• Molecular Weight: ~ 73kDa
• NCBI Official Full Name: potassium voltage-gated channel subfamily D member 3 isoform 1
• NCBI Official Synonym Full Names: potassium voltage-gated channel subfamily D member 3
• NCBI Official Symbol: KCND3
• NCBI Official Synonym Symbols: KV4.3; SCA19; SCA22; BRGDA9; KCND3L; KCND3S; KSHIVB
• NCBI Protein Information: potassium voltage-gated channel subfamily D member 3
• UniProt Protein Name: Potassium voltage-gated channel subfamily D member 3
• Protein Family: Potassium voltage-gated channel subfamily
• UniProt Gene Name: KCND3
• UniProt Entry Name: KCND3_HUMAN

NCBI Description

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Kv4.3: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. KCND3 rare variants may confer risk for lethal ventricular arrhytmias and be associated with autopsy-negative sudden unexplained death syndrome (SUDS). Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.3/KCND3 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, potassium; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p13.3

Cellular Component: voltage-gated potassium channel complex; cell soma; dendrite; plasma membrane; sarcolemma

Molecular Function: protein binding; metal ion binding; delayed rectifier potassium channel activity; A-type (transient outward) potassium channel activity

Biological Process: synaptic transmission; protein homooligomerization; potassium ion transport

Disease: Brugada Syndrome 9; Spinocerebellar Ataxia 19