Rabbit anti-Human KCND3 Polyclonal Antibody | anti-KCND3 antibody

KCND3, NT (KCND3, Potassium voltage-gated channel subfamily D member 3, Voltage-gated potassium channel subunit Kv4.3) (AP)

Cat. Num. AAA6312368

• Gene Names: KCND3; KV4.3; SCA19; SCA22; BRGDA9; KCND3L; KCND3S; KSHIVB
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: KCND3; Polyclonal Antibody; NT (KCND3; Potassium voltage-gated channel subfamily D member 3; Voltage-gated potassium channel subunit Kv4.3) (AP); Voltage-gated potassium channel subunit Kv4.3; anti-KCND3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).
• Sequence Length: 636

• Applicable Applications for anti-KCND3 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: KCND3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-41 amino acids from the N-terminal region of human KCND3.
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(KCND3 Antibody (N-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the KCND3 antibody detected the KCND3 protein (arrow).)

Related Product Information for anti-KCND3 antibody

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes-shaker, shaw, shab, and shal-have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene. [provided by RefSeq].

Product Categories/Family for anti-KCND3 antibody

Antibodies; Ion Channel

References

Lundby, A., et al. Br. J. Pharmacol. 160(8):2028-2044(2010). Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Liang, P., et al. Biophys. J. 98(12):2867-2876(2010). Cotella, D., et al. Pflugers Arch. 460(1):87-97(2010). Tan, X.Q., et al. Zhonghua Xin Xue Guan Bing Za Zhi 37(6):509-513(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 27436986
• NCBI GeneID: 3752
• NCBI Accession #: NP_751948.1; NP_004971.2
• NCBI GenBank Nucleotide #: NP_751948.1
• UniProt Accession #: Q9UK17
• NCBI Official Full Name: potassium voltage-gated channel subfamily D member 3 isoform 2
• NCBI Official Synonym Full Names: potassium voltage-gated channel subfamily D member 3
• NCBI Official Symbol: KCND3
• NCBI Official Synonym Symbols: KV4.3; SCA19; SCA22; BRGDA9; KCND3L; KCND3S; KSHIVB
• NCBI Protein Information: potassium voltage-gated channel subfamily D member 3
• UniProt Protein Name: Potassium voltage-gated channel subfamily D member 3
• Protein Family: Potassium voltage-gated channel subfamily
• UniProt Gene Name: KCND3
• UniProt Entry Name: KCND3_HUMAN

NCBI Description

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Kv4.3: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. KCND3 rare variants may confer risk for lethal ventricular arrhytmias and be associated with autopsy-negative sudden unexplained death syndrome (SUDS). Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.3/KCND3 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, potassium; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p13.3

Cellular Component: voltage-gated potassium channel complex; cell soma; dendrite; plasma membrane; sarcolemma

Molecular Function: protein binding; metal ion binding; delayed rectifier potassium channel activity; A-type (transient outward) potassium channel activity

Biological Process: synaptic transmission; protein homooligomerization; potassium ion transport

Disease: Brugada Syndrome 9; Spinocerebellar Ataxia 19