Western Blot (WB)
(KCND1 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the KCND1 antibody detected the KCND1 protein (arrow).)
Rabbit KCND1 Polyclonal Antibody | anti-KCND1 antibody
KCND1 Antibody (N-term)
Western Blot (WB)
(KCND1 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the KCND1 antibody detected the KCND1 protein (arrow).)
Western Blot (WB)
(KCND1 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the KCND1 antibody detected the KCND1 protein (arrow).)
complex class of voltage-gated ion channels from both functional
and structural standpoints. Their diverse functions include
regulating neurotransmitter release, heart rate, insulin secretion,
neuronal excitability, epithelial electrolyte transport, smooth
muscle contraction, and cell volume. Four sequence-related
potassium channel genes - shaker, shaw, shab, and shal - have been
identified in Drosophila, and each has been shown to have human
homolog(s). This gene encodes a member of the potassium channel,
voltage-gated, shal-related subfamily, members of which form
voltage-activated A-type potassium ion channels and are prominent
in the repolarization phase of the action potential. This gene is
expressed at moderate levels in all tissues analyzed, with lower
levels in skeletal muscle.
Gutman, G.A., et al. Pharmacol. Rev. 57(4):473-508(2005)
Jerng, H.H., et al. Biophys. J. 87(4):2380-2396(2004)
Nakamura, T.Y., et al. FEBS Lett. 499(3):205-209(2001)
Isbrandt, D., et al. Genomics 64(2):144-154(2000)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a multipass membrane protein that comprises the pore subunit of the voltage-gated A-type potassium channel, which functions in the repolarization of membrane action potentials. Activity of voltage-gated potassium channels is important in a number of physiological processes, among them the regulation of neurotransmitter release, heart rate, insulin secretion, and smooth muscle contraction. [provided by RefSeq, Aug 2013]
Uniprot Description
KCND1: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.1/KCND1 sub-subfamily.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: Xp11.23
Cellular Component: voltage-gated potassium channel complex; cell soma; dendrite; plasma membrane; integral to membrane
Molecular Function: delayed rectifier potassium channel activity; metal ion binding
Biological Process: synaptic transmission; protein homooligomerization
Research Articles on KCND1
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Product Notes
The KCND1 kcnd1 (Catalog #AAA9215208) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 118-147. The KCND1 Antibody (N-term) reacts with Human (Predicted Reactivity: Bovine, Mouse) and may cross-react with other species as described in the data sheet. AAA Biotech's KCND1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the KCND1 kcnd1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KCND1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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