Rabbit anti-Human KCND1 Polyclonal Antibody | anti-KCND1 antibody

KCND1, NT (KCND1, Potassium voltage-gated channel subfamily D member 1, Voltage-gated potassium channel subunit Kv4.1) (Biotin)

Cat. Num. AAA6312348

• Gene Names: KCND1; KV4.1
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: KCND1; Polyclonal Antibody; NT (KCND1; Potassium voltage-gated channel subfamily D member 1; Voltage-gated potassium channel subunit Kv4.1) (Biotin); Voltage-gated potassium channel subunit Kv4.1; anti-KCND1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-KCND1 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: KCND1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 117-147 amino acids from the N-terminal region of human KCND1.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(KCND1 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the KCND1 antibody detected the KCND1 protein (arrow).)

Related Product Information for anti-KCND1 antibody

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes-shaker, shaw, shab, and shal-have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This gene is expressed at moderate levels in all tissues analyzed, with lower levels in skeletal muscle.

Product Categories/Family for anti-KCND1 antibody

Antibodies; Ion Channel

References

Jang, S.H., et al. Biochem. Biophys. Res. Commun. 384(2):180-186(2009). Gutman, G.A., et al. Pharmacol. Rev. 57(4):473-508(2005). Jerng, H.H., et al. Biophys. J. 87(4):2380-2396(2004). Nakamura, T.Y., et al. FEBS Lett. 499(3):205-209(2001). Isbrandt, D., et al. Genomics 64(2):144-154(2000).

NCBI and Uniprot Product Information

• NCBI GI #: 27436981
• NCBI GeneID: 3750
• NCBI Accession #: NP_004970.3
• NCBI GenBank Nucleotide #: NM_004979.4
• UniProt Accession #: Q9NSA2; O75671; B2RCG0
• Molecular Weight: 71,330 Da
• NCBI Official Full Name: potassium voltage-gated channel subfamily D member 1
• NCBI Official Synonym Full Names: potassium voltage-gated channel, Shal-related subfamily, member 1
• NCBI Official Symbol: KCND1
• NCBI Official Synonym Symbols: KV4.1
• NCBI Protein Information: potassium voltage-gated channel subfamily D member 1; shal-type potassium channel; voltage-gated potassium channel Kv4.1; voltage-gated potassium channel subunit Kv4.1
• UniProt Protein Name: Potassium voltage-gated channel subfamily D member 1
• Protein Family: Potassium voltage-gated channel subfamily
• UniProt Gene Name: KCND1
• UniProt Entry Name: KCND1_HUMAN

NCBI Description

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This gene is expressed at moderate levels in all tissues analyzed, with lower levels in skeletal muscle. [provided by RefSeq, Jul 2008]

Uniprot Description

KCND1: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.1/KCND1 sub-subfamily.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: Xp11.23

Cellular Component: voltage-gated potassium channel complex; cell soma; dendrite; integral to membrane; plasma membrane

Molecular Function: delayed rectifier potassium channel activity; metal ion binding

Biological Process: synaptic transmission; protein homooligomerization