Rabbit anti-Human KCNA6 Polyclonal Antibody | anti-KCNA6 antibody

KCNA6 Antibody

Cat. Num. AAA7005707

• Gene Names: KCNA6; HBK2; KV1.6; PPP1R96
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: >95%,Protein G purified
• Synonyms: KCNA6; Polyclonal Antibody; KCNA6 Antibody; Potassium voltage-gated channel subfamily A member 6; Voltage-gated potassium channel HBK21; anti-KCNA6 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%,Protein G purified
• Form/Format: Liquid
• Sequence Length: 529

• Applicable Applications for anti-KCNA6 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Immunogen: Recombinant human Potassium voltage-gated channel subfamily A member 6 protein
• Conjugation: Non-conjugated
• Storage Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-16183 / sc-22943
• Preparation and Storage: Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human breast cancer using MBS7005707 at dilution of 1:100)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human liver cancer using MBS7005707 at dilution of 1:100)

Related Product Information for anti-KCNA6 antibody

Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed:2347305, PubMed:14575698). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:2347305, PubMed:14575698). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA6, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel. Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. Homotetrameric channels display rapid activation and slow inactivation (PubMed:2347305).

NCBI and Uniprot Product Information

• NCBI GI #: 4504821
• NCBI GeneID: 3742
• NCBI Accession #: NP_002226.1
• NCBI GenBank Nucleotide #: NM_002235.3
• UniProt Accession #: P17658
• Molecular Weight: 58,729 Da
• NCBI Official Full Name: potassium voltage-gated channel subfamily A member 6
• NCBI Official Synonym Full Names: potassium voltage-gated channel subfamily A member 6
• NCBI Official Symbol: KCNA6
• NCBI Official Synonym Symbols: HBK2; KV1.6; PPP1R96
• NCBI Protein Information: potassium voltage-gated channel subfamily A member 6
• UniProt Protein Name: Potassium voltage-gated channel subfamily A member 6
• Protein Family: Potassium voltage-gated channel subfamily
• UniProt Gene Name: KCNA6
• UniProt Entry Name: KCNA6_HUMAN

NCBI Description

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class. The coding region of this gene is intronless, and the gene is clustered with genes KCNA1 and KCNA5 on chromosome 12. [provided by RefSeq, Jul 2008]

Uniprot Description

Kv1.6: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.6/KCNA6 sub-subfamily.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: integral to plasma membrane; nerve terminal; plasma membrane; voltage-gated potassium channel complex

Molecular Function: delayed rectifier potassium channel activity; voltage-gated potassium channel activity

Biological Process: potassium ion transport; protein homooligomerization; synaptic transmission