Rabbit anti-Human KCNA6 Polyclonal Antibody | anti-KCNA6 antibody

KCNA6, NT (KCNA6, Potassium voltage-gated channel subfamily A member 6, Voltage-gated potassium channel HBK2, Voltage-gated potassium channel subunit Kv1.6) (Azide free) (HRP)

Cat. Num. AAA6312262

• Gene Names: KCNA6; HBK2; KV1.6; PPP1R96
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: KCNA6; Polyclonal Antibody; NT (KCNA6; Potassium voltage-gated channel subfamily A member 6; Voltage-gated potassium channel HBK2; Voltage-gated potassium channel subunit Kv1.6) (Azide free) (HRP); Voltage-gated potassium channel subunit Kv1.6; anti-KCNA6 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).

• Applicable Applications for anti-KCNA6 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: KCNA6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human KCNA6.
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(KCNA6 Antibody (N-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the KCNA6 antibody detected the KCNA6 protein (arrow).)

Related Product Information for anti-KCNA6 antibody

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes-shaker, shaw, shab, and shal-have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class. The coding region of this gene is intronless, and the gene is clustered with genes KCNA1 and KCNA5 on chromosome 12.

Product Categories/Family for anti-KCNA6 antibody

Antibodies; Ion Channel

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Tan, K.M., et al. Neurology 70(20):1883-1890(2008). Yusifov, T., et al. Proc. Natl. Acad. Sci. U.S.A. 105(1):376-381(2008). Lamesch, P., et al. Genomics 89(3):307-315(2007). Gutman, G.A., et al. Pharmacol. Rev. 57(4):473-508(2005).

NCBI and Uniprot Product Information

• NCBI GI #: 4504821
• NCBI GeneID: 3742
• NCBI Accession #: NP_002226.1
• NCBI GenBank Nucleotide #: NM_002235.3
• UniProt Accession #: P17658
• Molecular Weight: 58,729 Da
• NCBI Official Full Name: potassium voltage-gated channel subfamily A member 6
• NCBI Official Synonym Full Names: potassium voltage-gated channel subfamily A member 6
• NCBI Official Symbol: KCNA6
• NCBI Official Synonym Symbols: HBK2; KV1.6; PPP1R96
• NCBI Protein Information: potassium voltage-gated channel subfamily A member 6
• UniProt Protein Name: Potassium voltage-gated channel subfamily A member 6
• Protein Family: Potassium voltage-gated channel subfamily
• UniProt Gene Name: KCNA6
• UniProt Entry Name: KCNA6_HUMAN

NCBI Description

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class. The coding region of this gene is intronless, and the gene is clustered with genes KCNA1 and KCNA5 on chromosome 12. [provided by RefSeq, Jul 2008]

Uniprot Description

Kv1.6: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.6/KCNA6 sub-subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: voltage-gated potassium channel complex; integral to plasma membrane; plasma membrane; integral to membrane

Molecular Function: voltage-gated potassium channel activity; delayed rectifier potassium channel activity

Biological Process: synaptic transmission; protein homooligomerization; potassium ion transport