Rabbit JPH4 Polyclonal Antibody | anti-JPH4 antibody

JPH4 Antibody

Cat. Num. AAA9405095

• Gene Names: JPH4; JP4; JPHL1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity chromatography purified via peptide column
• Synonyms: JPH4; Polyclonal Antibody; JPH4 Antibody; Junctophilin 4; JPHL1; hJP-4; anti-JPH4 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 628

• Applicable Applications for anti-JPH4 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen Type: Peptide
• Immunogen Description: Raised against a 16 amino acid peptide near the carboxy terminus of human JPH4.
• Target Name: JPH4
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of JPH4 in 293 cell lysate with JPH4 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.)

Immunohistochemistry (IHC)

(Immunohistochemistry of JPH4 in human brain tissue with JPH4 antibody at 2.5 ug/mL.)

Related Product Information for anti-JPH4 antibody

Junctional complexes between the plasma membrane (PM) and endoplasmic/sarcoplasmic reticulum (ER/SR) are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. Junctophilins (JPs) are important components of the junctional complexes. JPs are composed of a carboxy-terminal hydrophobic segment spanning the ER/SR membrane and a remaining cytoplasmic domain that shows specific affinity for the PM. Four JPs have been identified as tissue-specific subtypes derived from different genes: JPH1 is expressed in skeletal muscle, JPH2 is detected throughout all muscle cell types, and JPH3 and JPH4 are predominantly expressed in the brain. In the CNS, both JPH3 and JPH4 are expressed throughout neural sites and contribute to the subsurface cistern formation in neurons. Mice lacking both JPH3 and JPH4 subtypes exhibit serious symptoms such as impaired learning and memory and are accompanied by abnormal nervous functions.

Product Categories/Family for anti-JPH4 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 33585440
• NCBI GeneID: 84502
• Molecular Weight: 65,861 Da
• NCBI Official Full Name: Junctophilin 4
• NCBI Official Synonym Full Names: junctophilin 4
• NCBI Official Symbol: JPH4
• NCBI Official Synonym Symbols: JP4; JPHL1
• NCBI Protein Information: junctophilin-4
• UniProt Protein Name: Junctophilin-4
• Protein Family: Junctophilin
• UniProt Gene Name: JPH4
• UniProt Synonym Gene Names: JPHL1; KIAA1831; JP-4
• UniProt Entry Name: JPH4_HUMAN

NCBI Description

This gene encodes a member of the junctophilin family of transmembrane proteins that are involved in the formation of the junctional membrane complexes between the plasma membrane and the endoplasmic/sarcoplasmic reticulum in excitable cells. The encoded protein contains a conserved N-terminal repeat region called the membrane occupation and recognition nexus sequence that is found in other members of the junctophilin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]

Uniprot Description

JPH4: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain- specific and appears to have an active role in certain neurons involved in motor coordination and memory. Belongs to the junctophilin family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 14q11

Cellular Component: smooth endoplasmic reticulum; plasma membrane; integral to membrane; dendritic shaft

Biological Process: regulation of synaptic plasticity; learning; neuromuscular process controlling balance