Western Blot (WB)
(Anti- Profilin2 antibody, MBS177064, Western blottingAll lanes: Anti Profilin2 (MBS177064) at 0.5ug/mlWB: Rat Brain Tissue Lysate at 50ugPredicted bind size: 15KDObserved bind size: 15KD )
Rabbit Profilin 2 Polyclonal Antibody | anti-PFN2 antibody
Anti-Profilin 2 antibody
Western Blot (WB)
(Anti- Profilin2 antibody, MBS177064, Western blottingAll lanes: Anti Profilin2 (MBS177064) at 0.5ug/mlWB: Rat Brain Tissue Lysate at 50ugPredicted bind size: 15KDObserved bind size: 15KD )
Western Blot (WB)
(Anti- Profilin2 antibody, MBS177064, Western blottingAll lanes: Anti Profilin2 (MBS177064) at 0.5ug/mlWB: Rat Brain Tissue Lysate at 50ugPredicted bind size: 15KDObserved bind size: 15KD )
Immunohistochemistry (IHC)
(Anti- Profilin2 antibody, MBS177064, IHC(P)IHC(P): Human Tonsil Tissue)
Immunohistochemistry (IHC)
(Anti- Profilin2 antibody, MBS177064, IHC(P)IHC(P): Human Tonsil Tissue)
Immunohistochemistry (IHC)
(Anti- Profilin2 antibody, MBS177064, IHC(P)IHC(P): Human Intestinal Cancer Tissue)
Immunohistochemistry (IHC)
(Anti- Profilin2 antibody, MBS177064, IHC(P)IHC(P): Human Intestinal Cancer Tissue)
Background: Profilin-2, also called PFN2, is a protein that in humans is encoded by the PFN2 gene. The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. This gene is mapped to 3q25.1. It is though to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene. It binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
profilin 2: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Belongs to the profilin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Actin-binding
Chromosomal Location of Human Ortholog: 3q25.1
Cellular Component: cytoskeleton; cytoplasm; terminal button
Molecular Function: actin monomer binding; protein binding; phosphatidylinositol-4,5-bisphosphate binding; adenyl-nucleotide exchange factor activity
Biological Process: positive regulation of actin filament polymerization; negative regulation of actin filament polymerization; positive regulation of ATPase activity; positive regulation of stress fiber formation; positive regulation of actin filament bundle formation; actin cytoskeleton organization and biogenesis; positive regulation of peptidyl-serine phosphorylation
Research Articles on PFN2
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Product Notes
The PFN2 pfn2 (Catalog #AAA177064) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Profilin 2 antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Profilin 2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin. Researchers should empirically determine the suitability of the PFN2 pfn2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Profilin 2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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