Western Blot (WB)
(JMJD2C Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the JMJD2C antibody detected the JMJD2C protein (arrow).)
Rabbit JMJD2C Polyclonal Antibody | anti-KDM4C antibody
JMJD2C Antibody (C-term)
Western Blot (WB)
(JMJD2C Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the JMJD2C antibody detected the JMJD2C protein (arrow).)
Western Blot (WB)
(JMJD2C Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the JMJD2C antibody detected the JMJD2C protein (arrow).)
Flow Cytometry (FC/FACS)
(JMJD2C Antibody (C-term) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Flow Cytometry (FC/FACS)
(JMJD2C Antibody (C-term) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
family and encodes a protein with one JmjC domain, one JmjN domain,
two PHD-type zinc fingers, and two Tudor domains. This nuclear
protein functions as a trimethylation-specific demethylase,
converting specific trimethylated histone residues to the
dimethylated form. Chromosomal aberrations and increased
transcriptional expression of this gene are associated with
esophageal squamous cell carcinoma. Alternative splicing results in
multiple transcript variants.
Suikki, H.E., et al. Prostate 70(8):889-898(2010)
Kantojarvi, K., et al. Psychiatr. Genet. 20(3):102-108(2010)
Liu, G., et al. Oncogene 28(50):4491-4500(2009)
Canova, C., et al. Cancer Res. 69(7):2956-2965(2009)
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the Jumonji domain 2 (JMJD2) family. The encoded protein is a trimethylation-specific demethylase, and converts specific trimethylated histone residues to the dimethylated form. This enzymatic action regulates gene expression and chromosome segregation. Chromosomal aberrations and changes in expression of this gene may be found in tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Uniprot Description
JMJD2C: the histone demethylase implicated in the epigenetic reprogramming during the early embryogenesis. Preferentially expressed in undifferentiated ES cells. JMJD2C, along with JMJD1A, regulate self-renewal in embryonic stem cells. Specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Two isoforms of the human protein are produced by alternative splicing.
Protein type: Demethylase; Oxidoreductase; EC 1.14.11.-
Chromosomal Location of Human Ortholog: 9p24.1
Cellular Component: nucleoplasm; nuclear chromatin
Molecular Function: enzyme binding; androgen receptor binding; dioxygenase activity; zinc ion binding; histone demethylase activity (H3-K9 specific)
Biological Process: regulation of transcription from RNA polymerase II promoter; establishment and/or maintenance of chromatin architecture; histone H3-K9 demethylation; transcription, DNA-dependent; positive regulation of cell proliferation
Research Articles on KDM4C
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Product Notes
The KDM4C kdm4c (Catalog #AAA9208112) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1023-1056. The JMJD2C Antibody (C-term) reacts with Human (Predicted Reactivity: Mouse) and may cross-react with other species as described in the data sheet. AAA Biotech's JMJD2C can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Flow Cytometry (FC/FACS). WB~~1:1000. Researchers should empirically determine the suitability of the KDM4C kdm4c for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "JMJD2C, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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