Structure
CDP-840 hydrochloride, Inhibitor
CDP-840 hydrochloride
Purity
>98% (HPLC)
Synonyms
CDP-840 hydrochloride; CDP840; L-765527; inhibitor
Purity/Purification
>98% (HPLC)
Target
PDE
Receptor
PDE
Chemical Name
4-[(2R)-2-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-phenylethyl]-pyridine hydrochloride
Molecular Formula
C25H27NO2.HCl
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for CDP-840 hydrochloride, inhibitor
CDP-840 (CDP840; L-765527) is a potent and selective PDE4 inhibitor with IC50 of 4-45nM for PDE 4 extracted from tissues or recombinant PDE 4 isoforms expressed in yeast; shows no effect for PDE-1, 2, 3, 5, and 7 (IC50>100uM), exhibits no significant selectivity in inhibiting human recombinant isoenzymes PDE-4A, B, C or D and is equally active against the isoenzymes lacking UCR1 (PDE-4B2 and PDE-4D2); causes a dose-dependent reduction of IL-5-induced pleural eosinophilia in rats (ED50=0.03mg/kg); prevents antigen-induced eosinophilia and bronchoconstriction; orally active. Asthma Phase 2 Discontinued
Product Categories/Family for CDP-840 hydrochloride, inhibitor
References
1. Hughes B, et al. Br J Pharmacol. 1996 Jul; 118 (5):1183-91.
2. Holbrook M, et al. Br J Pharmacol. 1996 Jul; 118 (5):1192-200.
3. Perry MJ, et al. Cell Biochem Biophys. 1998; 29 (1-2):113-32.
2. Holbrook M, et al. Br J Pharmacol. 1996 Jul; 118 (5):1192-200.
3. Perry MJ, et al. Cell Biochem Biophys. 1998; 29 (1-2):113-32.
Similar Products
Product Notes
The CDP-840 hydrochloride (Catalog #AAA3606961) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "CDP-840 hydrochloride, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
