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KDM4C recombinant protein
KDM4C recombinant protein
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SDS-PAGE
Scientific Background: KDM4C or lysine-specific demethylase 4C functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form (1). KDM4C is a member of the Jumonji domain 2 (JMJD2) family and contains one JmjC domain, one JmjN domain, two PHD-type zinc fingers, and two Tudor domains. KDM4C may contribute to tumor development and inhibition of KDM4C expression leads to decreased cell proliferation. KDM4C has been shown to play an important role in the development and/or progression of various types of cancer, including esophageal squamous cell carcinoma(2).
2. Yang, Z.-Q.et.a: Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in esophageal cancer cell lines. Cancer Res. 60: 4735-4739, 2000.
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein with one JmjC domain, one JmjN domain, two PHD-type zinc fingers, and two Tudor domains. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form. Chromosomal aberrations and increased transcriptional expression of this gene are associated with esophageal squamous cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Uniprot Description
Function: Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Ref.6
Cofactor: Binds 1 Fe2+ ion per subunit. Ref.7
Subcellular location: Nucleus
By similarity.
Tissue specificity: Overexpressed in several esophageal squamous cell carcinomas (ESCs). Ref.1
Domain: The 2 Tudor domains recognize and bind methylated histones. Double Tudor domain has an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails
By similarity.
Sequence similarities: Belongs to the JHDM3 histone demethylase family.Contains 1 JmjC domain.Contains 1 JmjN domain.Contains 2 PHD-type zinc fingers.Contains 2 Tudor domains.
Sequence caution: The sequence BAA34500.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.The sequence CAI39608.1 differs from that shown. Reason: Erroneous gene model prediction.
Research Articles on KDM4C
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Product Notes
The KDM4C kdm4c (Catalog #AAA515271) is a Recombinant Protein produced from Sf9 insect cells and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-460 with tag GST tag!!Expression System||Sf9 insect cells using baculovirus!!Source Note||Recombinant human KDM4C (1-460) was expressed by baculovirus in Sf9 insect cells. AAA Biotech's KDM4C can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the KDM4C kdm4c for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KDM4C, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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