Rabbit anti-Human, Mouse JAZF1 Polyclonal Antibody | anti-JAZF1 antibody

JAZF1 Antibody

Cat. Num. AAA9631083

• Gene Names: JAZF1; TIP27; ZNF802
• Reactivity: Human, Mouse
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: JAZF1; Polyclonal Antibody; JAZF1 Antibody; JAZF zinc finger 1; JAZF1_HUMAN; Juxtaposed with another zinc finger protein 1; TAK1 interacting protein 27; TAK1-interacting protein 27; TIP27; Zinc finger protein 802; ZNF802; anti-JAZF1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: JAZF1 Antibody detects endogenous levels of JAZF1.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-JAZF1 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from human JAZF1.
• Conjugation: Unconjugated
• Subunit Structure: Interacts with NR2C2 (via ligand-binding region).
• Tissue Specificity: Highest expression in testis with moderate levels in colon, placenta, prostate and ovary and low levels in brain, spleen, liver and small intestine.
• Function: Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2. Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity (By similarity). Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD (By similarity). Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue (By similarity). Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity (By similarity).
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-JAZF1 antibody

Nucleus; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 91822911
• NCBI GeneID: 221895
• NCBI Accession #: NP_778231.2
• NCBI GenBank Nucleotide #: NM_175061.3
• UniProt Accession #: Q86VZ6; Q8N3L7; A4D195
• Molecular Weight: 25,739 Da
• NCBI Official Full Name: juxtaposed with another zinc finger protein 1
• NCBI Official Synonym Full Names: JAZF zinc finger 1
• NCBI Official Symbol: JAZF1
• NCBI Official Synonym Symbols: TIP27; ZNF802
• NCBI Protein Information: juxtaposed with another zinc finger protein 1; TAK1-interacting protein 27; juxtaposed with another zinc finger gene 1; zinc finger protein 802
• UniProt Protein Name: Juxtaposed with another zinc finger protein 1
• Protein Family: Juxtaposed with another zinc finger protein
• UniProt Gene Name: JAZF1
• UniProt Synonym Gene Names: TIP27; ZNF802
• UniProt Entry Name: JAZF1_HUMAN

NCBI Description

This gene encodes a nuclear protein with three C2H2-type zinc fingers, and functions as a transcriptional repressor. Chromosomal aberrations involving this gene are associated with endometrial stromal tumors. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized [provided by RefSeq, Jul 2008]

Uniprot Description

JAZF1: Potential transcription factor. A chromosomal aberration involving JAZF1 may be a cause of endometrial stromal tumors. Translocation t(7;17)(p15;q21) with SUZ12. The translocation generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part of JAZF1 and the C-terminus part of SUZ12. It is frequently found in all cases of endometrial stromal tumors, except in endometrial stromal sarcomas, where it is rarer. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: C2H2-type zinc finger protein; Oncoprotein; Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 7p15.2-p15.1

Cellular Component: transcriptional repressor complex; nucleus

Molecular Function: nucleic acid binding; metal ion binding; transcription corepressor activity

Biological Process: transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter