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SDS-PAGE (K-562 cells were subjected to SDS PAGE followed by western blot with ITGB7 antibody at dilution of 1:1000)

Rabbit ITGB7 Polyclonal Antibody | anti-ITGB7 antibody

ITGB7 Antibody

Reactivity
Human, Mouse, Rat
Applications
ELISA, Western Blot, Immunohistochemistry
Purity
Antigen affinity purification
Synonyms
ITGB7; Polyclonal Antibody; ITGB7 Antibody; Integrin beta 7; integrin; beta 7; anti-ITGB7 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Antigen affinity purification
Sequence Length
798
Applicable Applications for anti-ITGB7 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes
WB: 1:500-1:5000
IHC: 1:20-1:200
Immunogen
Fusion protein of ITGB7
Calculated Molecular Weight
798aa; 87kd
Observed Molecular Weight
87kd
Buffer
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-6634 / sc-6635 / sc-15330
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles

SDS-PAGE

(K-562 cells were subjected to SDS PAGE followed by western blot with ITGB7 antibody at dilution of 1:1000)

SDS-PAGE (K-562 cells were subjected to SDS PAGE followed by western blot with ITGB7 antibody at dilution of 1:1000)

Immunohistochemistry

(Immunohistochemical of paraffin-embedded human lymphoma using ITGB7 antibody at dilution of 1:50 (under lOx lens))

Immunohistochemistry (Immunohistochemical of paraffin-embedded human lymphoma using ITGB7 antibody at dilution of 1:50 (under lOx lens))
Related Product Information for anti-ITGB7 antibody
BTN3A2, also named as Butyrophilin subfamily 3 member A2, is a 334 amino acid protein, which contains I Ig-like V-type (immunoglobulin-like) domain and belongs to the immunoglobulin superfamily. BTN3A2 plays a role in T-cell responses in the adaptive immune response and inhibits the release ofIFNG from activated T-cells. BTN3A2 can form Homodimer and is detected in T-cells and natural killer cells.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
71,582 Da
NCBI Official Full Name
ITGB7 protein
NCBI Official Synonym Full Names
integrin, beta 7
NCBI Official Symbol
ITGB7
NCBI Protein Information
integrin beta-7; gut homing receptor beta subunit; integrin beta 7 subunit
UniProt Protein Name
Integrin beta-7
Protein Family
UniProt Gene Name
ITGB7
UniProt Entry Name
ITB7_HUMAN

NCBI Description

This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms dimers with an alpha4 chain or an alphaE chain and plays a role in leukocyte adhesion. Dimerization with alpha4 forms a homing receptor for migration of lymphocytes to the intestinal mucosa and Peyer's patches. Dimerization with alphaE permits binding to the ligand epithelial cadherin, a calcium-dependent adhesion molecule. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]

Uniprot Description

ITGB7: integrin alpha-4/beta-7 (Peyer's patches-specific homing receptor lpam-1) is expected to play a role in adhesive interactions of leukocytes. It is a receptor for fibronectin and recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Integrin alpha-4/beta-7 is also a receptor for MADCAM1 and VCAM1. It recognizes the sequence L-D-T in MADCAM 1. Integrin alpha-e/beta-7 (HML-1) is a receptor for e-cadherin. Two alternatively spliced isoforms have been described.

Protein type: Membrane protein, integral; Receptor, misc.; Motility/polarity/chemotaxis; Cell adhesion

Chromosomal Location of Human Ortholog: 12q13.13

Cellular Component: cell surface; membrane; plasma membrane; integrin complex; receptor complex

Molecular Function: viral receptor activity; protein binding; metal ion binding; cell adhesion molecule binding

Biological Process: integrin-mediated signaling pathway; heterotypic cell-cell adhesion; entry of virus into host cell; extracellular matrix organization and biogenesis; regulation of immune response; multicellular organismal development; cell-matrix adhesion; cell adhesion; leukocyte tethering or rolling; receptor clustering

Research Articles on ITGB7

Similar Products

Product Notes

The ITGB7 itgb7 (Catalog #AAA2523350) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ITGB7 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's ITGB7 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). WB: 1:500-1:5000 IHC: 1:20-1:200. Researchers should empirically determine the suitability of the ITGB7 itgb7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ITGB7, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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