Rabbit ITGB7 Polyclonal Antibody | anti-ITGB7 antibody

ITGB7 Polyclonal Antibody

Cat. Num. AAA2529759

• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: ITGB7; Polyclonal Antibody; ITGB7 Polyclonal Antibody; anti-ITGB7 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 2.5mg/mL (varies by lot)
• Sequence Length: 798

• Applicable Applications for anti-ITGB7 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:100-1:300
• Immunogen: Synthetic peptide of human ITGB7
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using ITGB7 Polyclonal Antibody at dilution of 1:40)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human gastric cancer using ITGB7 Polyclonal Antibody at dilution of 1:40)

Related Product Information for anti-ITGB7 antibody

This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms dimers with an alpha4 chain or an alphaE chain and plays a role in leukocyte adhesion. Dimerization with alpha4 forms a homing receptor for migration of lymphocytes to the intestinal mucosa and Peyer's patches. Dimerization with alphaE permits binding to the ligand epithelial cadherin, a calcium-dependent adhesion molecule. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

Product Categories/Family for anti-ITGB7 antibody

Stem Cells

NCBI and Uniprot Product Information

• NCBI GI #: 16198471
• NCBI GeneID: 3695
• Molecular Weight: 71,582 Da
• NCBI Official Full Name: ITGB7 protein
• NCBI Official Synonym Full Names: integrin, beta 7
• NCBI Official Symbol: ITGB7
• NCBI Protein Information: integrin beta-7; gut homing receptor beta subunit; integrin beta 7 subunit
• UniProt Protein Name: Integrin beta-7
• Protein Family: Integrin
• UniProt Gene Name: ITGB7
• UniProt Entry Name: ITB7_HUMAN

NCBI Description

This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms dimers with an alpha4 chain or an alphaE chain and plays a role in leukocyte adhesion. Dimerization with alpha4 forms a homing receptor for migration of lymphocytes to the intestinal mucosa and Peyer's patches. Dimerization with alphaE permits binding to the ligand epithelial cadherin, a calcium-dependent adhesion molecule. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]

Uniprot Description

ITGB7: integrin alpha-4/beta-7 (Peyer's patches-specific homing receptor lpam-1) is expected to play a role in adhesive interactions of leukocytes. It is a receptor for fibronectin and recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Integrin alpha-4/beta-7 is also a receptor for MADCAM1 and VCAM1. It recognizes the sequence L-D-T in MADCAM 1. Integrin alpha-e/beta-7 (HML-1) is a receptor for e-cadherin. Two alternatively spliced isoforms have been described.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion; Receptor, misc.

Chromosomal Location of Human Ortholog: 12q13.13

Cellular Component: cell surface; membrane; plasma membrane; integrin complex; receptor complex

Molecular Function: viral receptor activity; protein binding; metal ion binding; cell adhesion molecule binding

Biological Process: integrin-mediated signaling pathway; heterotypic cell-cell adhesion; entry of virus into host cell; regulation of immune response; extracellular matrix organization and biogenesis; multicellular organismal development; cell-matrix adhesion; cell adhesion; leukocyte tethering or rolling; receptor clustering