Western Blot (WB)
(PDE4C Antibody (N-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the PDE4C antibody detected the PDE4C protein (arrow).)
Rabbit anti-Human PDE4C Polyclonal Antibody | anti-PDE4C antibody
PDE4C Antibody (N-term)
Western Blot (WB)
(PDE4C Antibody (N-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the PDE4C antibody detected the PDE4C protein (arrow).)
Western Blot (WB)
(PDE4C Antibody (N-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the PDE4C antibody detected the PDE4C protein (arrow).)
regulate and mediate a number of cellular responses to
extracellular signals, such as hormones, light, and
neurotransmitters. Cyclic nucleotide phosphodiesterases (PDEs)
regulate the cellular concentrations of cyclic nucleotides and
thereby play a role in signal transduction. PDE4C is a class IV
cAMP-specific PDE (summary by Milatovich et al., 1994 [PubMed
8009369]).
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)
Sullivan, M., et al. Cell. Signal. 11(10):735-742(1999)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
Uniprot Description
PDE4C: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: Phosphodiesterase; Nucleotide Metabolism - purine; EC 3.1.4.53
Chromosomal Location of Human Ortholog: 19p13.11
Cellular Component: extracellular space; cytosol
Molecular Function: 3',5'-cyclic-AMP phosphodiesterase activity; metal ion binding
Biological Process: cAMP catabolic process; signal transduction
Research Articles on PDE4C
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Product Notes
The PDE4C pde4c (Catalog #AAA9203048) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 5-31. The PDE4C Antibody (N-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PDE4C can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the PDE4C pde4c for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PDE4C, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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