Western Blot (WB)
(IRX5 Antibody (C-term) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the IRX5 antibody detected the IRX5 protein (arrow).)
Rabbit anti-Human, mouse IRX5 Polyclonal Antibody | anti-IRX5 antibody
IRX5 Antibody (C-term)
Western Blot (WB)
(IRX5 Antibody (C-term) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the IRX5 antibody detected the IRX5 protein (arrow).)
Western Blot (WB)
(IRX5 Antibody (C-term) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the IRX5 antibody detected the IRX5 protein (arrow).)
Members of this family appear to play multiple roles during pattern
formation of vertebrate embryos.
Bruneau, B.G. Med Sci (Paris) 22(3):231-232(2006)
Ogura, K., et al. Cytogenet. Cell Genet. 92 (3-4), 320-325 (2001) :
Lewis, M.T., et al. Cell Tissue Res. 296(3):549-554(1999)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the iroquois homeobox gene family, which are involved in several embryonic developmental processes. Knockout mice lacking this gene show that it is required for retinal cone bipolar cell differentiation, and that it negatively regulates potassium channel gene expression in the heart to ensure coordinated cardiac repolarization. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Uniprot Description
IRX5: Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and control specific aspects of visual function in circuits of the mammalian retina. Could be involved in the regulation of both the cell cycle and apoptosis in prostate cancer cells. Involved in craniofacial and gonadal development. Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing CXCL12. Defects in IRX5 are the cause of Hamamy syndrome (HMMS). A sydrome characterized by severe hypertelorism, upslanting palpebral fissures, brachycephaly, abnormal ears, sloping shoulders, enamel hypoplasia, and osteopenia with repeated fractures. Additional features include myopia, mild to moderate sensorineural hearing loss, gonadal anomalies, and borderline intelligence. Belongs to the TALE/IRO homeobox family.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 16q12.2
Cellular Component: nucleus
Molecular Function: vitamin D binding; sequence-specific DNA binding
Biological Process: gonad development; visual perception; transcription, DNA-dependent; regulation of transcription, DNA-dependent; regulation of heart rate; response to stimulus; embryonic cranial skeleton morphogenesis; neuron maturation; retinal bipolar neuron differentiation
Disease: Hamamy Syndrome
Research Articles on IRX5
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Product Notes
The IRX5 irx5 (Catalog #AAA9208541) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 455-483. The IRX5 Antibody (C-term) reacts with Human, mouse and may cross-react with other species as described in the data sheet. AAA Biotech's IRX5 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the IRX5 irx5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IRX5, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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