Rabbit anti-Human, Mouse IRF7 Polyclonal Antibody | anti-IRF7 antibody

IRF7 Polyclonal Antibody

Cat. Num. AAA3008711

• Gene Names: IRF7; IMD39; IRF-7; IRF7A; IRF7B; IRF7C; IRF7H; IRF-7H
• Reactivity: Human, Mouse
• Applications: Western Blot, Immunofluorescence
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: IRF7; Polyclonal Antibody; IRF7 Polyclonal Antibody; IRF-7H; IRF7A; Interferon regulatory factor 7; anti-IRF7 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: IRF7 polyclonal antibody detects endogenous levels of IRF7 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 503

• Applicable Applications for anti-IRF7 antibody: Western Blot (WB), Immunofluorescence (IF)
• Application Notes: WB: 1:500-1:2000; IF: 1:50-1:200
• Immunogen: A synthetic peptide of human IRF7.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot analysis of extracts of various cell lines, using IRF7 antibody.)

Immunofluorescence (IF)

(Immunofluorescence analysis of U2OS cells using IRF7 antibody.)

Related Product Information for anti-IRF7 antibody

Interferon regulatory factors (IRFs) comprise a family of transcription factors that function within the Jak/Stat pathway to regulate interferon (IFN) and IFN-inducible gene expression in response to viral infection (1). IRFs play an important role in pathogen defense, autoimmunity, lymphocyte development, cell growth, and susceptibility to transformation. The IRF family includes nine members: IRF-1, IRF-2, ISGF3gamma/p48, IRF-3, IRF-4 (Pip/LSIRF/ICSAT), IRF-5, IRF-6, IRF-7, and IRF-8/ICSBP. All IRF proteins share homology in their amino-terminal DNA-binding domains. IRF family members regulate transcription through interactions with proteins that share similar DNA-binding motifs, such as IFN-stimulated response elements (ISRE), IFN consensus sequences (ICS), and IFN regulatory elements (IRF-E) (2).IRF-7, which is functionally similar to IRF-3, is preferentially expressed in lymphoid cells and induced by virus, LPS, and IFN-alpha (3-5). IRF-7 plays an essential role in the induction of type I interferon in response viral infecton (6-8). Like IRF-3, IRF-7 is regulated at multiple serine phosphorylation sites near its carboxyl terminus, which are required for nuclear translocation, DNA binding, and transcriptional activity (9-11).

NCBI and Uniprot Product Information

• NCBI GI #: 4758610
• NCBI GeneID: 3665
• NCBI Accession #: NP_001563.2
• NCBI GenBank Nucleotide #: NP_001563.2
• UniProt Accession #: Q92985
• Molecular Weight: ~ 70kDa
• NCBI Official Full Name: interferon regulatory factor 7 isoform a
• NCBI Official Synonym Full Names: interferon regulatory factor 7
• NCBI Official Symbol: IRF7
• NCBI Official Synonym Symbols: IMD39; IRF-7; IRF7A; IRF7B; IRF7C; IRF7H; IRF-7H
• NCBI Protein Information: interferon regulatory factor 7
• UniProt Protein Name: Interferon regulatory factor 7
• Protein Family: Interferon regulatory factor
• UniProt Gene Name: IRF7
• UniProt Synonym Gene Names: IRF-7
• UniProt Entry Name: IRF7_HUMAN

NCBI Description

IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established. [provided by RefSeq, Jul 2008]