Rabbit anti-Human IRF7 Polyclonal Antibody | anti-IRF7 antibody

IRF7 Antibody

Cat. Num. AAA9413391

• Gene Names: IRF7; IMD39; IRF7A; IRF7B; IRF7C; IRF7H; IRF-7H
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: IRF7; Polyclonal Antibody; IRF7 Antibody; IRF7A; IRF-7H; anti-IRF7 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total IRF7 protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
• Concentration: 0.4 mg/ml (varies by lot)
• Sequence Length: 503

• Applicable Applications for anti-IRF7 antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:10-1:50
• Immunogen Type: Peptide
• Immunogen Description: Synthetic peptide corresponding to residues near the C terminal of human interferon regulatory factor 7
• Target Name: IRF7
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using at dilution 1/15.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue using at dilution 1/15.)

Related Product Information for anti-IRF7 antibody

IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established.

Product Categories/Family for anti-IRF7 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 4758610
• NCBI GeneID: 3665
• NCBI Accession #: NP_001563.2
• NCBI GenBank Nucleotide #: NM_001572.3
• UniProt Accession #: Q92985; O00331; O00332; O00333; O75924; Q9UE79; B9EGL3
• Molecular Weight: 55,635 Da
• NCBI Official Full Name: interferon regulatory factor 7 isoform a
• NCBI Official Synonym Full Names: interferon regulatory factor 7
• NCBI Official Symbol: IRF7
• NCBI Official Synonym Symbols: IMD39; IRF7A; IRF7B; IRF7C; IRF7H; IRF-7H
• NCBI Protein Information: interferon regulatory factor 7
• UniProt Protein Name: Interferon regulatory factor 7
• Protein Family: Interferon regulatory factor
• UniProt Gene Name: IRF7
• UniProt Synonym Gene Names: IRF-7
• UniProt Entry Name: IRF7_HUMAN

NCBI Description

IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established. [provided by RefSeq, Jul 2008]

Uniprot Description

Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages.