Rabbit anti-Human IP10 Polyclonal Antibody | anti-CXCL10 antibody

Anti-IP10 antibody

Cat. Num. AAA175477

• Gene Names: CXCL10; C7; IFI10; INP10; IP-10; crg-2; mob-1; SCYB10; gIP-10
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry
• Purity: Immunogen affinity purified.
• Synonyms: IP10; Polyclonal Antibody; Anti-IP10 antibody; C-X-C motif chemokine 10; chemokine(C-X-C motif) ligand 10; 10 kDa interferon gamma induced protein antibody; 10 kDa interferon gamma-induced protein antibody; C X C motif chemokine 10 antibody; C7 antibody; Chemokine(C X C motif) ligand 10 antibody; Chemokine CXC motif ligand 10 antibody; Crg 2 antibody; CRG2 antibody; CXCL 10 antibody; CXCL10 antibody; CXCL10(1-73) antibody; CXL10_HUMAN antibody; Gamma IP10 antibody; Gamma-IP10 antibody; gIP 10 antibody; GIP10 antibody; IFI 10 antibody; IFI10 antibody; INP 10 antibody; INP10 antibody; Interferon activated gene 10 antibody; Interferon gamma induced cell line antibody; Interferon inducible cytokine IP 10 antibody; Interferon inducible cytokine IP10 antibody; IP 10 antibody; IP-10 antibody; Mob 1 antibody; MOB1 antibody; Protein 10 from interferon(gamma) induced cell line antibody; SCYB 10 antibody; SCYB10 antibody; Small inducible cytokine B10 antibody; Small inducible cytokine B10 precursor antibody; Small inducible cytokine subfamily B(Cys X Cys) member 10 antibody; Small inducible cytokine subfamily B CXC member 10 antibody; Small-inducible cytokine B10 antibody; anti-CXCL10 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Immunogen affinity purified.
• Form/Format: Lyophilized
• Sequence Length: 98

• Applicable Applications for anti-CXCL10 antibody: Western Blot (WB), Immunohistochemistry (IHC) Paraffin
• Application Notes: Western Blot (WB); Concentration: 0.1-0.5ug/ml; Tested Species: Hu; ; Immunohistochemistry (IHC):; Concentration: 0.5-1ug/ml; Tested Species: Hu; Antigen Retrieval: By Heat; ; Tested Species: In-house tested species with positive results.; Predict Species: Species predicted to be fit for the product based on sequence similarities.; By heat: Boiling the pearaffin sections in 10mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin section.; Other applications have not been tested.; Optimal dilutions should be determined by end users.
• Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human CXCL10 (79-98aa SKAIKNLLKAVSKERSKRSP).
• Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
• Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
• Preparation and Storage: At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Western Blot (WB)

(Anti-IP10 antibody, MBS175477, Western blottingLane 1: Recombinant Human CXCL10 Protein 10ngLane 2: Recombinant Human CXCL10 Protein 5ngLane 3: Recombinant Human CXCL10 Protein 2.5ng )

Immunohistochemistry (IHC)

(Anti-IP10 antibody, MBS175477, IHC(P)IHC(P): Human Mammary Cancer Tissue )

Related Product Information for anti-CXCL10 antibody

Description: Rabbit IgG polyclonal antibody for C-X-C motif chemokine 10(CXCL10) detection. Tested with WB, IHC-P in Human.
Background: C-X-C motif chemokine 10(CXCL10), also known as Interferon gamma-induced protein 10 kDa(IP-10) or small-inducible cytokine B10, is a protein that in humans is encoded by the CXCL10 gene. It is a small cytokine belonging to the CXC chemokine family. The gene for CXCL10 is located on human chromosome 4 in a cluster among several other CXC chemokines. Luster et al.(1987) reported the isolation of an interferon-inducible gene that encodes a 98-amino acid protein called IP10. The chemokine IFN-gamma-inducible protein 10(IP-10; CXCL10), a CXC chemokine, and its receptor, CXCR3, were found to be overexpressed in lymph node cells of EAMG rats. IP10 inhibits bone marrow colony formation, has antitumor activity in vivo, is a chemoattractant for human monocytes and T cells, and promotes T cell adhesion to endothelial cells.

NCBI and Uniprot Product Information

• NCBI GI #: 21542456
• NCBI GeneID: 3627
• UniProt Accession #: P02778; Q96QJ5
• Molecular Weight: 10,881 Da
• NCBI Official Full Name: C-X-C motif chemokine 10
• NCBI Official Synonym Full Names: chemokine (C-X-C motif) ligand 10
• NCBI Official Symbol: CXCL10
• NCBI Official Synonym Symbols: C7; IFI10; INP10; IP-10; crg-2; mob-1; SCYB10; gIP-10
• NCBI Protein Information: C-X-C motif chemokine 10; gamma IP10; gamma-IP10; small-inducible cytokine B10; interferon-inducible cytokine IP-10; 10 kDa interferon gamma-induced protein; protein 10 from interferon (gamma)-induced cell line; small inducible cytokine subfamily B (Cys-X-Cys), member 10
• UniProt Protein Name: C-X-C motif chemokine 10
• Protein Family: C-X-C motif chemokine
• UniProt Gene Name: CXCL10
• UniProt Synonym Gene Names: INP10; SCYB10; Gamma-IP10; IP-10
• UniProt Entry Name: CXL10_HUMAN

NCBI Description

This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Sep 2014]

Uniprot Description

CXCL10: Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis; Chemokine

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular space; extracellular region; external side of plasma membrane

Molecular Function: heparin binding; protein binding; CXCR3 chemokine receptor binding; chemokine activity; cAMP-dependent protein kinase regulator activity; receptor binding

Biological Process: muscle development; blood circulation; protein secretion; positive regulation of leukocyte chemotaxis; positive regulation of cAMP metabolic process; signal transduction; chemotaxis; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; cell surface receptor linked signal transduction; response to vitamin D; cell-cell signaling; positive regulation of cell proliferation; response to gamma radiation; positive regulation of transcription from RNA polymerase II promoter; immune response; response to cold; positive regulation of release of sequestered calcium ion into cytosol; regulation of protein kinase activity; inflammatory response; negative regulation of myoblast differentiation; defense response to virus